Overview

Description

  • Nature
    Synthetic

Associated products

Specifications

Our Abpromise guarantee covers the use of ab156928 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-HSD17B6 antibody (ab62221)

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

General Info

  • Alternative names
    • 17-beta-HSD 6
    • 17-beta-HSD6
    • 17-beta-hydroxysteroid dehydrogenase type 6
    • 3 hydroxysteroid epimerase
    • 3(alpha >beta) hydroxysteroid epimerase
    • 3(alpha >beta) hydroxysteroid epimerasel
    • 3-alpha->beta-HSE
    • 3-alpha->beta-hydroxysteroid epimerase
    • H17B6_HUMAN
    • HSD17B6
    • HSE
    • Hydroxysteroid (17 beta) dehydrogenase 6
    • Hydroxysteroid (17 beta) dehydrogenase 6 homolog (mouse)
    • Hydroxysteroid 17 beta dehydrogenase 6
    • NAD+ dependent 3 alpha hydroxysteroid dehydrogenase
    • NAD+ dependent 3 alpha hydroxysteroid dehydrogenase 3 hydroxysteroid epimerase
    • Oxidative 3 alpha hydroxysteroid dehydrogenase
    • Oxidative 3-alpha hydroxysteroid dehydrogenase
    • Oxidoreductase
    • Retinol dehydrogenase
    • RODH
    • SDR9C6
    • Short chain dehydrogenase/reductase family 9C, member 6
    see all
  • Function
    NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha-androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids.
  • Tissue specificity
    Detected in liver and prostate (at protein level). Detected in adult liver, lung, brain, placenta, prostate, adrenal gland, testis, mammary gland, spleen, spinal cord and uterus. Detected in caudate nucleus, and at lower levels in amygdala, corpus callosum, hippocampus, substantia nigra and thalamus. Detected in fetal lung, liver and brain.
  • Sequence similarities
    Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  • Cellular localization
    Microsome membrane. Early endosome membrane.
  • Information by UniProt

References

ab156928 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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