Overview

  • Product name
    Anti-HSD17B7 antibody
  • Description
    Rabbit polyclonal to HSD17B7
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Recombinant fragment, corresponding to amino acids 35-221 of Human HSD17B7 (BC007068).

  • Positive control
    • 293T and MCF7 cell lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab112006 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 33 kDa (predicted molecular weight: 38 kDa).

Target

  • Function
    Responsible for the reduction of the keto group on the C-3 of sterols.
  • Tissue specificity
    Highly expressed in adrenal gland, liver, lung and thymus. Expressed in breast, ovaries, pituitary gland, pregnant uterus, prostate, kidney, lymph node, small intestine, spinal cord and trachea. Weakly expressed in all other tissues tested. Isoform 3 is expressed in eye ciliary epithelial cells and neuroendocrine cells.
  • Pathway
    Steroid biosynthesis; estrogen biosynthesis.
    Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 5/6.
  • Sequence similarities
    Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily.
  • Post-translational
    modifications
    Phosphorylated.
  • Cellular localization
    Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • 17 beta HSD 7 antibody
    • 17 beta hydroxysteroid dehydrogenase 7 antibody
    • 17 beta hydroxysteroid dehydrogenase type VII antibody
    • 17-beta-HSD 7 antibody
    • 17-beta-hydroxysteroid dehydrogenase 7 antibody
    • 17beta hydroxysteroid dehydrogenase antibody
    • 3 keto steroid reductase antibody
    • 3-keto-steroid reductase antibody
    • DHB7_HUMAN antibody
    • Estradiol 17 beta dehydrogenase 7 antibody
    • Estradiol 17-beta-dehydrogenase 7 antibody
    • Hsd17b7 antibody
    • Hydroxysteroid (17 beta) dehydrogenase 7 antibody
    • MGC12523 antibody
    • MGC75018 antibody
    • PRAP antibody
    • SDR37C1 antibody
    • Short chain dehydrogenase/reductase family 37C member 1 antibody
    see all

Images

  • All lanes : Anti-HSD17B7 antibody (ab112006) at 1/500 dilution

    Lane 1 : 293T cell lysate
    Lane 2 : MCF7 cell lysate


    Predicted band size : 38 kDa

References

This product has been referenced in:
  • Wang X  et al. Synergistic control of sex hormones by 17ß-HSD type 7: a novel target for estrogen-dependent breast cancer. J Mol Cell Biol 7:568-79 (2015). Read more (PubMed: 25966904) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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