Overview

  • Product name
  • Description
    Rabbit polyclonal to HSF4
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region between N terminal amino acids 99-128 of Human HSF4 (NP_001529.2, NP_001035757.1).

  • Positive control
    • HL60 cell line lysates

Properties

Applications

Our Abpromise guarantee covers the use of ab124111 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 53 kDa.

Target

  • Function
    DNA-binding protein that specifically binds heat shock promoter elements (HSE). Isoform HSF4A represses transcription while the isoform HSF4B activates transcription.
  • Tissue specificity
    Expressed in heart, skeletal muscle, eye and brain, and at much lower levels in some other tissues.
  • Involvement in disease
    Defects in HSF4 are the cause of cataract zonular HSF4-related (CZ-HSF4) [MIM:116800]. A form of zonular cataract. Zonular or lamellar cataracts are opacities, broad or narrow, usually consisting of powdery white dots affecting only certain layers or zones between the cortex and nucleus of an otherwise clear lens. The opacity may be so dense as to render the entire central region of the lens completely opaque, or so translucent that vision is hardly if at all impeded. Zonular cataracts generally do not involve the embryonic nucleus, though sometimes they involve the fetal nucleus. Usually sharply separated from a clear cortex outside them, they may have projections from their outer edges known as riders or spokes.
    Defects in HSF4 are the cause of cataract Marner type (CAM) [MIM:116800]. A form of cataract with variable and progressive opacities. Affected individuals present with zonular cataract, although some have nuclear, anterior polar, or stellate cataract. Finger malformation is observed in some kindreds.
  • Sequence similarities
    Belongs to the HSF family.
  • Post-translational
    modifications
    Phosphorylated mainly on serine residues. Phosphorylation on Ser-298 promotes sumoylation on Lys-293.
    Isoform HSF4B is constitutively sumoylated. Sumoylation represses the transcriptional activity and is promoted by phosphorylation on Ser-298. HSFA is not sumoylated.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • Cataract, Marner antibody
    • CTM antibody
    • Heat shock factor protein 4 antibody
    • Heat shock transcription factor 4 antibody
    • hHSF4 antibody
    • HSF 4 antibody
    • HSF4 antibody
    • HSF4_HUMAN antibody
    • HSTF 4 antibody
    see all

Images

  • Anti-HSF4 antibody (ab124111) at 1/100 dilution + HL60 cell line lysates at 35 µg

    Predicted band size : 53 kDa

References

ab124111 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab124111.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up