Overview

Description

  • Nature
    Synthetic

Associated products

Specifications

Our Abpromise guarantee covers the use of ab40009 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    Blocking - Blocking peptide for Anti-Hsp90 antibody (ab19021)

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: 0.02% Thimerosal (merthiolate)
    Constituents: 0.1% BSA, PBS, pH 7.2

General Info

  • Alternative names
    • Heat shock 86 kDa
    • Heat shock protein 90kDa alpha cytosolic class A member 1
    • Heat shock protein 90kDa alpha cytosolic class B member 1
    • Heat shock protein HSP 90 alpha
    • Heat shock protein HSP 90 beta
    • Heat shock protein HSP 90-alpha
    • HS90A_HUMAN
    • HSP 84
    • HSP 86
    • Hsp 90
    • HSP86
    • HSP90A
    • HSP90AA1
    • HSP90AB1
    • HSP90B
    • HSPC1
    • HSPC2
    • HSPCAL1
    • HSPCAL4
    • Renal carcinoma antigen NY-REN-38
    see all
  • Function
    Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.
  • Sequence similarities
    Belongs to the heat shock protein 90 family.
  • Domain
    The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins like the co-chaperone STUB1.
  • Post-translational
    modifications
    ISGylated.
    S-nitrosylated; negatively regulates the ATPase activity and the activation of eNOS by HSP90AA1.
  • Cellular localization
    Cytoplasm. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
  • Information by UniProt

References

ab40009 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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