Overview

  • Product nameAnti-HSP90B2P antibody
  • Description
    Rabbit polyclonal to HSP90B2P
  • Tested applicationsSuitable for: WB, ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Chicken, Human, Drosophila melanogaster, Monkey
    Predicted to work with: Rabbit, Cow, Dog, Pig, Xenopus laevis, Zebrafish, Cynomolgus Monkey, Syrian Hamster, Orangutan
  • Immunogen

    Synthetic peptide corresponding to Human HSP90B2P aa 289-300 (C terminal).
    Sequence:

    SQYGWSGNMERI

  • Positive control
    • Human kidney tissue.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: 0.01% Sodium Azide
    Constituents: 0.15M Sodium chloride, 0.02M Potassium phosphate, pH 7.2
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab64182 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/2500. Predicted molecular weight: 46 kDa.
ELISA 1/5000 - 1/25000.
IHC-P Use a concentration of 2.5 µg/ml.

Target

  • RelevanceHsp90 is a member of the heat shock protein 90 family that functions as a molecular chaperone and has ATPase activity. Hsp90 family proteins are highly conserved between isoforms and species. Several signal transduction pathways depend on Hsp90 function including erbB2, steroid hormone receptors (such as androgen, progesterone, glucocorticoid, and aryl-hydrocarbon), and hypoxia sensing (Hif1alpha). Recent reports show that tumor cells are more sensitive to Hsp90 inhibition and that Hsp90 from tumor cells is more sensitive to small molecule inhibitors (eg 17AAG). The mechanism of this differential sensitivity of normal versus tumor Hsp90 is not known (although mutation has been ruled out). One possible mechanism may be differences in post-translational modification of tumor Hsp90. Hsp90 is a cytoplasmic protein that forms a homodimer in vivo, and interacts with TOM34, AHSA1, HDAC6 and SMYD3.
  • Cellular localizationEndoplasmic reticulum
  • Database links
  • Alternative names
    • GRP94P1 antibody
    • Heat shock protein 90kDa beta (Grp94) member 2 antibody
    • HSP antibody
    • HSPCP2 antibody
    • Putative endoplasmin like protein antibody
    • Putative heat shock protein 90 kDa beta member 2 antibody
    • TRA1P1 antibody
    • TRAP1 antibody
    see all

Anti-HSP90B2P antibody images

  • ab64182 (2.5ug/ml) staining HSP90B2P in human kidney tissue by immunohistochemistry using formalin-fixed, paraffin-embedded tissue.

References for Anti-HSP90B2P antibody (ab64182)

ab64182 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"