General notesab94320 is a 293T cell transfected lysate in which Human HspBP1 has been transiently over-expressed using a pCMV-HspBP1 plasmid. The lysate is provided in 1X Sample Buffer.
Note: For more details about how the transfected lysate was prepared view preparation notes
BackgroundFunction: Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR.
Tissue specificity: Ubiquitous.
Similarity: Contains 4 ARM repeats.