Anti-HSV1 + HSV2 gD antibody [2C10] (ab6507)
- Datasheet
- Specific References (9)
- Protocols
Overview
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Product nameAnti-HSV1 + HSV2 gD antibody [2C10]
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DescriptionMouse monoclonal [2C10] to HSV1 + HSV2 gD
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Host speciesMouse
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Tested applicationsSuitable for: WB, ELISA, ICC/IFmore details
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Immunogen
Herpes Virus
Properties
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FormLiquid
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Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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Storage bufferPhosphate buffered saline
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Concentration information loading... -
PurityProtein A purified
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ClonalityMonoclonal
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Clone number2C10
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MyelomaNS1/1-Ag4-1
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IsotypeIgG2a
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Light chain typekappa
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Research areas
Associated products
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Compatible Secondaries
Applications
Our Abpromise guarantee covers the use of ab6507 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| WB | 1/10000. | |
| ELISA | 1/102400. | |
| ICC/IF | 1/3200 - 1/25600. 1/3,200 (HSV-2) - 1/25,600 (HSV-1). |
Target
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RelevanceHerpes simplex virus 1 and 2 (HSV-1 and HSV-2) are two species of the herpes virus family, Herpesviridae, which cause infections in humans. They are also called Human Herpes Virus 1 and 2 (HHV-1 and HHV-2) and are neurotropic and neuroinvasive viruses; they enter and hide in the human nervous system, accounting for their durability in the human body. Under a microscope, HSV- 1 and 2 are virtually identical, sharing approximately 50% of their DNA. Both types infect the body's mucosal surfaces, usually the mouth or genitals, and then establish latency in the nervous system. HSV-1 is commonly associated with herpes outbreaks of the face known as cold sores or fever blisters, whereas HSV-2 is more often associated with genital herpes. Herpes simplex viruses (HSV) use multiple and sequential receptors to enter host cells. HSV glycoprotein D (gD) has been implicated in binding to cellular receptors that facilitate virus penetration into cells. Herpes simplex virus type 1 (HSV-1) glycoprotein D (gD) is an essential component of the entry apparatus that is responsible for viral penetration and subsequent cell-cell spread.
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Alternative names
- Envelope glycoprotein D antibody
- GD antibody
- Glycoprotein D antibody
- US6 antibody
Images
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![Western blot - Anti-HSV1 + HSV2 gD antibody [2C10] (ab6507)](http://a.abcam.com/ps/products/6/ab6507/Images/ab6507.jpg)
Western blot - Anti-HSV1 + HSV2 gD antibody [2C10] (ab6507)The WB was completed using the HSV-1 Antigen and the HSV-2 Infected Cell Extract at 10 µg/cm -
![Immunocytochemistry/ Immunofluorescence - Anti-HSV1 + HSV2 gD antibody [2C10] (ab6507)](http://a.abcam.com/ps/products/6/ab6507/Images/ab6507-296194-ab6507iccif.jpg)
Immunocytochemistry/ Immunofluorescence - Anti-HSV1 + HSV2 gD antibody [2C10] (ab6507)Immunocytochemistry/Immunofluorescence analysis of vero cells infected with HSV1 (left) or HSV2 (right) labelled with ab6507.
References
This product has been referenced in:
- Aravantinou M et al. Experimental Oral Herpes Simplex Virus-1 (HSV-1) Co-infection in Simian Immunodeficiency Virus (SIV)-Infected Rhesus Macaques. Front Microbiol 8:2342 (2017). ELISA . Read more (PubMed: 29259582) »
- Çuburu N et al. Topical herpes simplex virus 2 (HSV-2) vaccination with human papillomavirus vectors expressing gB/gD ectodomains induces genital-tissue-resident memory CD8+ T cells and reduces genital disease and viral shedding after HSV-2 challenge. J Virol 89:83-96 (2015). WB . Read more (PubMed: 25320297) »
Customer reviews and Q&As
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"