Anti-HTLV I gp46 antibody [68/4.11.21] (ab9083)

Overview

  • Product name
    Anti-HTLV I gp46 antibody [68/4.11.21]
    See all HTLV I gp46 primary antibodies
  • Description
    Mouse monoclonal [68/4.11.21] to HTLV I gp46
  • Specificity
    Reacts with Human T-Lymphotropic Virus Type I (HTLV I) surface protein, gp46. Reacts strongly with MTA-4 recombinant HTLV I env. No reactivity with the surface protein of HTLV II (MoT) has been observed.
  • Tested applications
    Suitable for: Radioimmunoprecipitation, WB, ELISA, ICC/IFmore details
  • Epitope
    The epitope is located between amino acids 190-209 of the viral env gene.
  • General notes


    The antibody is used to detect HTLV I surface protein and its precursor in lysates prepared from virons or infected cells. Using immunoblotting and/or radioimmunoprecipitation analysis, the biosynthesis and metabolism of viral surface protein may be studied.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer
    Preservative: None
    Constituents: PBS, pH 7.2
  • Concentration information loading...
  • Purity
    Ammonium Sulphate Precipitation
  • Purification notes
    Purified from serum-free culture supernatant.
  • Primary antibody notes
    The antibody is used to detect HTLV I surface protein and its precursor in lysates prepared from virons or infected cells. Using immunoblotting and/or radioimmunoprecipitation analysis, the biosynthesis and metabolism of viral surface protein may be studied.
  • Clonality
    Monoclonal
  • Clone number
    68/4.11.21
  • Isotype
    IgG1
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab9083 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Radioimmunoprecipitation Use at an assay dependent dilution.
WB Use a concentration of 1 - 10 µg/ml.
ELISA Use at an assay dependent dilution.
ICC/IF Use a concentration of 1 - 10 µg/ml.

Target

  • Relevance
    HTLV I gp46 surface protein is processed from its precursor gp62. It attaches the virus to the host cell by binding to its receptor. This interaction triggers the refolding of the transmembrane protein (TM) and is thought to activate its fusogenic potential by unmasking its fusion peptide. Fusion occurs at the host cell plasma membrane.
  • Cellular localization
    Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein
  • Alternative names
    • Glycoprotein 46 antibody
    • SU antibody
    • Surface protein antibody

References

ab9083 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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