Overview

  • Product nameAnti-HtrA2 / Omi antibody
    See all HtrA2 / Omi primary antibodies
  • Description
    Rabbit polyclonal to HtrA2 / Omi
  • SpecificityThis antibody recognizes the full length and the mitochondria processed HtrA2/Omi.
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Recombinant full length HtrA2/Omi protein (Human).

Properties

Applications

Our Abpromise guarantee covers the use of ab18895 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 48 kDa.

Target

  • FunctionSerine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive.
  • Tissue specificityIsoform 1 is ubiquitous. Isoform 2 is expressed predominantly in the kidney, colon and thyroid.
  • Involvement in diseaseDefects in HTRA2 are the cause of Parkinson disease type 13 (PARK13) [MIM:610297]. A complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain.
  • Sequence similaritiesBelongs to the peptidase S1B family.
    Contains 1 PDZ (DHR) domain.
  • DomainThe mature N-terminus is involved in the interaction with XIAP.
    The PDZ domain mediates interaction with MXI2.
  • Post-translational
    modifications
    Autoproteolytically activated.
  • Cellular localizationMitochondrion intermembrane space. Mitochondrion membrane. Predominantly present in the intermembrane space. Released into the cytosol following apoptotic stimuli, such as UV treatment, and stimulation of mitochondria with caspase-8 truncated BID/tBID.
  • Information by UniProt
  • Database links
  • Alternative names
    • High temperature requirement protein A2 antibody
    • HTRA 2 antibody
    • HtrA like serine protease antibody
    • HtrA serine peptidase 2 antibody
    • HtrA, E. coli, homolog of, 2 antibody
    • HtrA2 antibody
    • HTRA2_HUMAN antibody
    • mitochondrial antibody
    • Omi stress regulated endoprotease antibody
    • Omi stress-regulated endoprotease antibody
    • PARK 13 antibody
    • PARK13 antibody
    • Protease serine 25 antibody
    • PRSS 25 antibody
    • PRSS25 antibody
    • Serine protease 25 antibody
    • Serine protease HTRA2 antibody
    • Serine protease HTRA2 mitochondrial antibody
    • Serine protease htra2 mitochondrial precursor antibody
    • Serine protease omi antibody
    • Serine proteinase OMI antibody
    see all

References for Anti-HtrA2 / Omi antibody (ab18895)

ab18895 has not yet been referenced specifically in any publications.

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