Anti-HtrA2 / Omi antibody (ab36854)

Overview

• Product nameAnti-HtrA2 / Omi antibody
  See all HtrA2 / Omi primary antibodies
• Description
  Rabbit polyclonal to HtrA2 / Omi
• Tested applicationsSuitable for: WB, ICC/IF, IHC-Pmore details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Synthetic peptide corresponding to 16 amino acids near the C-terminus of human OMI.

• Positive control
  • U937 cell lysate.

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Store at +4°C.
• Storage bufferPreservative: 0.02% Sodium Azide
  Constituents: PBS
• Concentration information loading...
• PurityIgG fraction
• Purification notesPurified by Ion exchange chromatography.
• ClonalityPolyclonal
• IsotypeIgG
• Research areas
  • Neuroscience
  • Neurology process
  • Neurodegenerative disease
  • Parkinson's disease
  • Parkin / PARK

  • Cell Biology
  • Apoptosis
  • Mitochondrial

  • Cell Biology
  • Other Antibodies
  • Oxidative Stress

  • Cancer
  • Invasion/microenvironment
  • Apoptosis
  • Other

  • Metabolism
  • Pathways and Processes
  • Mitochondrial Metabolism
  • Mitochondrial markers

  • Metabolism
  • Pathways and Processes
  • Redox metabolism
  • Oxidative stress

  • Metabolism
  • Pathways and Processes
  • Metabolism processes
  • Apoptosis

  • Cancer
  • Cell Death
  • Apoptosis
  • Other

  • Cancer
  • Cell Death
  • Apoptosis
  • Mitochondrial

  • Cancer
  • Cell Death
  • Apoptosis
  • Metabolism

Associated products

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

Applications

Target

• FunctionSerine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive.
• Tissue specificityIsoform 1 is ubiquitous. Isoform 2 is expressed predominantly in the kidney, colon and thyroid.
• Involvement in diseaseDefects in HTRA2 are the cause of Parkinson disease type 13 (PARK13) [MIM:610297]. A complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain.
• Sequence similaritiesBelongs to the peptidase S1B family.
  Contains 1 PDZ (DHR) domain.
• DomainThe mature N-terminus is involved in the interaction with XIAP.
  The PDZ domain mediates interaction with MXI2.
• Post-translational
  modificationsAutoproteolytically activated.
• Cellular localizationMitochondrion intermembrane space. Mitochondrion membrane. Predominantly present in the intermembrane space. Released into the cytosol following apoptotic stimuli, such as UV treatment, and stimulation of mitochondria with caspase-8 truncated BID/tBID.

• Target information above from: UniProt accession O43464 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• Database links
  • Entrez Gene: 27429 Human
  • Omim: 606441 Human
  • SwissProt: O43464 Human
  • Unigene: 469045 Human
  • Unigene: 744841 Human
• Alternative names
  • High temperature requirement protein A2 antibody
  • HTRA 2 antibody
  • HtrA like serine protease antibody

  • HtrA serine peptidase 2 antibody
  • HtrA, E. coli, homolog of, 2 antibody
  • HtrA2 antibody
  • HTRA2_HUMAN antibody
  • mitochondrial antibody
  • Omi stress regulated endoprotease antibody
  • Omi stress-regulated endoprotease antibody
  • PARK 13 antibody
  • PARK13 antibody
  • Protease serine 25 antibody
  • PRSS 25 antibody
  • PRSS25 antibody
  • Serine protease 25 antibody
  • Serine protease HTRA2 antibody
  • Serine protease HTRA2 mitochondrial antibody
  • Serine protease htra2 mitochondrial precursor antibody
  • Serine protease omi antibody
  • Serine proteinase OMI antibody

  see all