Overview

  • Product nameAnti-HUCE1 antibody
    See all HUCE1 primary antibodies
  • Description
    Mouse polyclonal to HUCE1
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length Human HUCE1 (NP_056139.1)

  • Positive control
    • HeLa cell lysate, HUCE1 transfected 293T cell lysate.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: 1X PBS, pH 7.2
  • Concentration information loading...
  • PurityProtein A purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Associated products

Applications

Our Abpromise guarantee covers the use of ab89478 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 51 kDa.

Target

  • FunctionEssential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.
  • Sequence similaritiesBelongs to the methyltransferase superfamily. RRP8 family.
  • Cellular localizationNucleus > nucleolus. Localizes at rDNA locus.
  • Information by UniProt
  • Database links
  • Alternative names
    • Cerebral protein 1 antibody
    • hypothetical protein LOC23378 antibody
    • KIAA0409 antibody
    • Nucleomethylin antibody
    • Ribosomal RNA processing 8 methyltransferase homolog antibody
    • Ribosomal RNA processing 8, methyltransferase, homolog (yeast) antibody
    • Ribosomal RNA processing protein 8 antibody
    • Ribosomal RNA-processing protein 8 antibody
    • RRP 8 antibody
    • RRP8 antibody
    • RRP8 methyltransferase homolog antibody
    • RRP8_HUMAN antibody
    see all

Anti-HUCE1 antibody images

References for Anti-HUCE1 antibody (ab89478)

ab89478 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"