Human 14-3-3 Tau full length protein (ab70352)

Overview

Description

  • NatureRecombinant
  • SourceE. coli
  • Amino Acid Sequence
    • SpeciesHuman
    • Amino acids0 to 0

Specifications

Our Abpromise guarantee covers the use of ab70352 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

  • Purity> 95 % by SDS-PAGE.
    The purity was determined to be >95% by densitometry.
  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM PMSF, pH 7.5

General info

  • Alternative names
    • 14 3 3 protein T cell
    • 14 3 3 protein tau
    • 14 3 3 protein theta
    • 14 3 3 tau
    • 14 3 3 theta
    • 14-3-3 protein T-cell
    • 14-3-3 protein tau
    • 14-3-3 protein theta
    • 1433T_HUMAN
    • 1C5
    • HS1
    • KCIP1
    • Protein HS1
    • Protein kinase C inhibitor protein 1
    • Protein tau
    • tyr3/trp5 monooxygenase activation protein, theta
    • Tyrosine 3 monooxygenase/tryptophan 5 monooxygenase activation protein, theta polypeptide
    • YWHAQ
    see all
  • FunctionAdapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.
  • Tissue specificityAbundantly expressed in brain, heart and pancreas, and at lower levels in kidney and placenta. Up-regulated in the lumbar spinal cord from patients with sporadic amyotrophic lateral sclerosis (ALS) compared with controls, with highest levels of expression in individuals with predominant lower motor neuron involvement.
  • Sequence similaritiesBelongs to the 14-3-3 family.
  • Post-translational
    modifications
    Ser-232 is probably phosphorylated by CK1.
  • Cellular localizationCytoplasm. In neurons, axonally transported to the nerve terminals.
  • Information by UniProt

Human 14-3-3 Tau full length protein images

  • SDS-PAGE showing ab70532 14-3-3 Tau protein at approximately 56kDa.

References for Human 14-3-3 Tau full length protein (ab70352)

ab70352 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab70352.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"