Overview

  • Product nameHuman 53BP1 peptide

Description

  • NatureSynthetic

Specifications

Our Abpromise guarantee covers the use of ab98293 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Purity70 - 90% by HPLC.

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

General info

  • Alternative names
    • 53 BP1
    • 53BP1
    • FLJ41424
    • MGC138366
    • p202
    • p53 binding protein 1
    • p53 BP1
    • p53-binding protein 1
    • p53BP1
    • TP53 BP1
    • TP53B_HUMAN
    • Tp53bp1
    • TRP53 BP1
    • Tumor protein 53 binding protein 1
    • Tumor protein p53 binding protein 1
    • Tumor suppressor p53 binding protein 1
    • Tumor suppressor p53-binding protein 1
    see all
  • FunctionMay have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation. Plays a role in the response to DNA damage.
  • Involvement in diseaseNote=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein.
  • Sequence similaritiesContains 2 BRCT domains.
  • Post-translational
    modifications
    Asymmetrically dimethylated on Arg residues by PRMT1. Methylation is required for DNA binding.
    Phosphorylated at basal level in the absence of DNA damage. Hyper-phosphorylated in an ATM-dependent manner in response to DNA damage induced by ionizing radiation. Hyper-phosphorylated in an ATR-dependent manner in response to DNA damage induced by UV irradiation.
  • Cellular localizationNucleus. Chromosome > centromere > kinetochore. Associated with kinetochores. Both nuclear and cytoplasmic in some cells. Recruited to sites of DNA damage, such as double stand breaks. Methylation of histone H4 at 'Lys-20' is required for efficient localization to double strand breaks.
  • Information by UniProt

References for Human 53BP1 peptide (ab98293)

ab98293 has not yet been referenced specifically in any publications.

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