Human Acetyl Coenzyme A carboxylase alpha full length protein (ab79625)

Overview

Description

  • NatureRecombinant
  • SourceBaculovirus infected sf9 cells
  • Amino Acid Sequence
    • SpeciesHuman
    • Amino acids39 to 2346

Specifications

Our Abpromise guarantee covers the use of ab79625 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Store at -20°C, Stable for 6 months at -20°C

    Preservative: None
    Constituents: 10% Glycerol, 0.05% Tween 20, 50mM Tris HCl, 3mM DTT, 150mM Sodium chloride, 0.1mM EDTA, 0.1mM EGTA, pH 7.5

General info

  • Alternative names
    • ACAC
    • ACACA
    • ACACA
    • ACACA_HUMAN
    • ACC alpha
    • ACC-alpha
    • ACC1
    • ACC1
    • ACCA
    • acetyl Coenzyme A
    • Acetyl Coenzyme A
    • Biotin carboxylase
    see all
  • FunctionCatalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.
  • Tissue specificityExpressed in brain, placental, skeletal muscle, renal, pancreatic and adipose tissues; expressed at low level in pulmonary tissue; not detected in the liver.
  • PathwayLipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.
  • Involvement in diseaseDefects in ACACA are a cause of acetyl-CoA carboxylase 1 deficiency (ACACAD) [MIM:200350]; also known as ACAC deficiency or ACC deficiency. An inborn error of de novo fatty acid synthesis associated with severe brain damage, persistent myopathy and poor growth.
  • Sequence similaritiesContains 1 ATP-grasp domain.
    Contains 1 biotin carboxylation domain.
    Contains 1 biotinyl-binding domain.
    Contains 1 carboxyltransferase domain.
  • Post-translational
    modifications
    Phosphorylation on Ser-1263 is required for interaction with BRCA1.
  • Cellular localizationCytoplasm.
  • Information by UniProt

References for Human Acetyl Coenzyme A carboxylase alpha full length protein (ab79625)

ab79625 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab79625.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"