Human Acetyl Coenzyme A carboxylase alpha full length protein (ab79625)
- Product nameHuman Acetyl Coenzyme A carboxylase alpha full length proteinSee all Acetyl Coenzyme A carboxylase alpha proteins and peptides ...
- SourceBaculovirus infected sf9 cells
- Amino Acid Sequence
- Amino acids39 to 2346
Our Abpromise guarantee covers the use of ab79625 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- Concentration information loading...
Preparation and Storage
- Stability and Storage
Store at -20°C, Stable for 6 months at -20°C
Constituents: 10% Glycerol, 0.05% Tween 20, 50mM Tris HCl, 3mM DTT, 150mM Sodium chloride, 0.1mM EDTA, 0.1mM EGTA, pH 7.5
- ACC alpha
- acetyl Coenzyme A
- Acetyl Coenzyme A
- Biotin carboxylase
- FunctionCatalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.
- Tissue specificityExpressed in brain, placental, skeletal muscle, renal, pancreatic and adipose tissues; expressed at low level in pulmonary tissue; not detected in the liver.
- PathwayLipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.
- Involvement in diseaseDefects in ACACA are a cause of acetyl-CoA carboxylase 1 deficiency (ACACAD) [MIM:200350]; also known as ACAC deficiency or ACC deficiency. An inborn error of de novo fatty acid synthesis associated with severe brain damage, persistent myopathy and poor growth.
- Sequence similaritiesContains 1 ATP-grasp domain.
Contains 1 biotin carboxylation domain.
Contains 1 biotinyl-binding domain.
Contains 1 carboxyltransferase domain.
modificationsPhosphorylation on Ser-1263 is required for interaction with BRCA1.
- Cellular localizationCytoplasm.
References for Human Acetyl Coenzyme A carboxylase alpha full length protein (ab79625)
ab79625 has not yet been referenced specifically in any publications.