Human active + pro Caspase 3 peptide (ab13848)

Overview

  • Product nameHuman active + pro Caspase 3 peptide

Description

  • NatureSynthetic
  • SourceCHO
  • Amino Acid Sequence
    • AccessionP42574
    • SpeciesHuman

Specifications

Our Abpromise guarantee covers the use of ab13848 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-active + pro Caspase 3 antibody (ab13847), Anti-active Caspase-3 antibody (ab77973)

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

General info

  • Alternative names
    • APOPAIN
    • Apopain precursor
    • Apopain precursor
    • CASP 3
    • CASP-3
    • CASP3
    • CASP3
    • CASP3_HUMAN
    • Caspase 3
    • Caspase 3 apoptosis related cysteine protease
    • Caspase 3 apoptosis related cysteine protease
    • Caspase-3 subunit p12
    • Caspase3
    • CPP 32
    • CPP 32
    • CPP-32
    • CPP32
    • CPP32B
    • CPP32B
    • Cysteine protease CPP32
    • Cysteine protease CPP32
    • Human cysteine protease CPP32 isoform alpha mRNA complete cds
    • Human cysteine protease CPP32 isoform alpha mRNA complete cds
    • ICE3
    • ICE3
    • LICE
    • LICE
    • PARP cleavage protease
    • PARP cleavage protease
    • Protein Yama
    • SCA 1
    • SCA-1
    • SCA1
    • SREBP cleavage activity 1
    • SREBP cleavage activity 1
    • Yama
    • Yama protein
    • Yama protein
    see all
  • RelevanceCaspases are a family of cysteine proteases that are key mediators of programmed cell death or apoptosis. The precursor form of all caspases is composed of a prodomain, and large and small catalytic subunits. The active forms of caspases are generated by several stimuli including ligand receptor interactions, growth factor deprivation and inhibitors of cellular functions. All known caspases require cleavage adjacent to aspartates to liberate one large and one small subunit, which associate into a2b2 tetramer to form the active enzyme. Gene for Caspase 3 also known as Yama, CPP32, and apopain codes for a 32-kDa protein. Caspase 3 cleaves the death substrate poly(ADP ribose) polymerase (PARP) to a specific 85 kDa form observed during apoptosis and is inhibitable by the CrmA protein. Other Caspase 3 substrates include DNA-PK, actin, GAS2, and procaspase 6, etc. Caspase 3 is activated by cleavage events at Asp-28/Ser-29 (between N-terminal pro domain) and Asp-175/Ser-176 (between large and small subunits) to generate a large subunit of 17 kDa and a small subunit of 12 kDa.
  • Cellular localizationCytoplasmic

References for Human active + pro Caspase 3 peptide (ab13848)

ab13848 has not yet been referenced specifically in any publications.

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