Overview

Description

  • NatureSynthetic
  • SourceCHO

Specifications

Our Abpromise guarantee covers the use of ab13848 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-active + pro Caspase 3 antibody (ab13847), Anti-active Caspase 3 antibody (ab77973)

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

General info

  • Alternative names
    • APOPAIN
    • Apopain precursor
    • Apopain precursor
    • CASP3
    • CASP3
    • Caspase 3 apoptosis related cysteine protease
    • Caspase 3 apoptosis related cysteine protease
    • Caspase3
    • CPP 32
    • CPP 32
    • CPP32
    • CPP32B
    • CPP32B
    • Cysteine protease CPP32
    • Cysteine protease CPP32
    • Human cysteine protease CPP32 isoform alpha mRNA complete cds
    • Human cysteine protease CPP32 isoform alpha mRNA complete cds
    • ICE3
    • ICE3
    • LICE
    • LICE
    • PARP cleavage protease
    • PARP cleavage protease
    • SCA 1
    • SCA1
    • SREBP cleavage activity 1
    • SREBP cleavage activity 1
    • Yama
    • Yama protein
    • Yama protein
    see all
  • RelevanceThe caspase family of cysteine proteases play a key role in apoptosis. Caspase 3 is the most extensively studied apoptotic protein among caspase family members. Caspase 3 is synthesized as inactive pro enzyme that is processed in cells undergoing apoptosis by self proteolysis and/or cleavage by other upstream proteases (e.g. Caspases 8, 9 and 10). The processed form of Caspase 3 consists of large (17kDa) and small (12kDa) subunits which associate to form an active enzyme. Caspase 3 is cleaved at Asp28 Ser29 and Asp175 Ser176. The active Caspase 3 proteolytically cleaves and activates other caspases (e.g. Caspases 6, 7 and 9), as well as relevant targets in the cells (e.g. PARP and DFF). Alternative splicing of this gene results in two transcript variants which encode the same protein. In immunohistochemical studies Caspase 3 expression has been shown to be widespread but not present in all cell types (e.g. commonly reported in epithelial cells of skin, renal proximal tubules and collecting ducts). Differences in the level of Caspase 3 have been reported in cells of short lived nature (eg germinal centre B cells) and those that are long lived (eg mantle zone B cells). Caspase 3 is the predominant caspase involved in the cleavage of amyloid beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease.
  • Cellular localizationCytoplasmic

References for Human active Caspase 3 peptide (ab13848)

ab13848 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab13848.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"