Human Activin Receptor Type IIB protein fragment (ab125577)
- Product nameHuman Activin Receptor Type IIB protein fragmentSee all Activin Receptor Type IIB proteins and peptides ...
- SourceBaculovirus infected sf9 cells
- Amino Acid Sequence
- Molecular weight61 kDa including tags
- Amino acids182 to 488
Our Abpromise guarantee covers the use of ab125577 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- Purity> 85
Purity determined to be >85% by densitometry.
- Concentration information loading...
Preparation and Storage
- Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
Constituents: 0.31% Glutathione, 0.002% PMSF, 0.004% DTT, 0.79% Tris HCl, 0.003% EDTA, 25% Glycerol, 0.29% Sodium chloride
- Activin A receptor type IIB
- Activin receptor type 2B
- Activin receptor type IIB
- Activin receptor type-2B
- ActR IIB
- ACVR 2B
- FunctionOn ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.
- Involvement in diseaseDefects in ACVR2B are the cause of visceral heterotaxy autosomal type 4 (HTX4) [MIM:613751]. A form of visceral heterotaxy, a complex disorder due to disruption of the normal left-right asymmetry of the thoracoabdominal organs. It results in an abnormal arrangement of visceral organs, and a wide variety of congenital defects. Clinical features of visceral heterotaxy type 4 include dextrocardia, right aortic arch and a right-sided spleen, anomalies of the inferior and the superior vena cava, atrial ventricular canal defect with dextro-transposed great arteries, pulmonary stenosis, polysplenia and midline liver.
- Sequence similaritiesBelongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Contains 1 protein kinase domain.
- Cellular localizationMembrane.
References for Human Activin Receptor Type IIB protein fragment (ab125577)
ab125577 has not yet been referenced specifically in any publications.