Human ACVRL1 peptide (ab23196)
- Product nameHuman ACVRL1 peptideSee all ACVRL1 proteins and peptides ...
- Amino Acid Sequence
- Amino acids491 to 503
Our Abpromise guarantee covers the use of ab23196 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- Concentration information loading...
Preparation and Storage
- Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
- Activin A receptor
- Activin A receptor type II like 1
- Activin A receptor, type II like kinase 1
- Activin receptor like kinase 1
- Activin receptor-like kinase 1
- Osler Rendu Weber syndrome 2
- Serine/threonine protein kinase receptor R3
- Serine/threonine-protein kinase receptor R3
- TGF B superfamily receptor type I
- TGF-B superfamily receptor type I
- FunctionOn ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta. May bind activin as well.
- Involvement in diseaseDefects in ACVRL1 are the cause of hereditary hemorrhagic telangiectasia type 2 (HHT2) [MIM:600376]; also known as Osler-Rendu-Weber syndrome 2 (ORW2). HHT2 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary, cerebral and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia.
- Sequence similaritiesBelongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Contains 1 GS domain.
Contains 1 protein kinase domain.
- Cellular localizationMembrane.
References for Human ACVRL1 peptide (ab23196)
ab23196 has not yet been referenced specifically in any publications.