Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      C-NRNNSSGRVPTII
    • Amino acids
      845 to 857

Specifications

Our Abpromise guarantee covers the use of ab23095 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • AGAP 1
    • AGAP-1
    • Agap1
    • AGAP1_HUMAN
    • Arf GAP with GTP binding proteinlike ANK repeat and PH domains 1
    • Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1
    • ArfGAP with GTPase domain ankyrin repeat and PH domain 1
    • Centaurin gamma 2
    • Centaurin-gamma-2
    • CENTG2
    • Cnt-g2
    • GGAP 1
    • GGAP1
    • GTP binding and GTPase activating protein 1
    • GTP-binding and GTPase-activating protein 1
    • KIAA1099
    • MGC71657
    see all
  • Function
    GTPase-activating protein for ARF1 and, to a lesser extent, ARF5. Directly and specifically regulates the adapter protein 3 (AP-3)-dependent trafficking of proteins in the endosomal-lysosomal system.
  • Tissue specificity
    Widely expressed.
  • Sequence similarities
    Belongs to the centaurin gamma-like family.
    Contains 2 ANK repeats.
    Contains 1 Arf-GAP domain.
    Contains 1 PH domain.
  • Domain
    The PH domain mediates AP-3 binding.
  • Post-translational
    modifications
    Phosphorylated on tyrosines.
  • Cellular localization
    Cytoplasm. Associates with the endocytic compartment.
  • Information by UniProt

References

ab23095 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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