The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Arf GAP with GTP binding proteinlike ANK repeat and PH domains 1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1
ArfGAP with GTPase domain ankyrin repeat and PH domain 1
Centaurin gamma 2
GTP binding and GTPase activating protein 1
GTP-binding and GTPase-activating protein 1
FunctionGTPase-activating protein for ARF1 and, to a lesser extent, ARF5. Directly and specifically regulates the adapter protein 3 (AP-3)-dependent trafficking of proteins in the endosomal-lysosomal system.
Tissue specificityWidely expressed.
Sequence similaritiesBelongs to the centaurin gamma-like family. Contains 2 ANK repeats. Contains 1 Arf-GAP domain. Contains 1 PH domain.
DomainThe PH domain mediates AP-3 binding.
Post-translational modificationsPhosphorylated on tyrosines.
Cellular localizationCytoplasm. Associates with the endocytic compartment.