• NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • Amino acids650 to 662


Our Abpromise guarantee covers the use of ab45572 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications


  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

General Info

  • Alternative names
    • 1500031L16Rik
    • A kinase (PRKA) anchor protein 10
    • A kinase anchor protein 10
    • A kinase anchor protein 10 mitochondrial
    • A-kinase anchor protein 10
    • AKA10_HUMAN
    • akap 10
    • AKAP-10
    • AKAP10
    • B130049N18Rik
    • D AKAP 2
    • D-AKAP-2
    • dakap 2
    • dakap2
    • Dual specific A kinase anchoring protein 2
    • Dual specificity A kinase-anchoring protein 2
    • mgc9410
    • MGC9414|
    • mitochondrial
    • Mitochondrial A kinase PPKA anchor protein 10
    • prka 10
    • PRKA10
    • Protein A kinase anchoring protein 10
    • Protein A kinase anchoring protein 10 mitochondrial precursor
    • Protein kinase A anchoring protein 10
    • Protein kinase A-anchoring protein 10
    see all
  • FunctionDifferentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase.
  • Involvement in diseaseGenetic variations in AKAP10 are a cause of susceptibility to sudden cardiac death (SCD) [MIM:115080]. Unexpected rapid natural death due to cardiovascular collapse within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as chest pain and cardiac arrhythmias, particularly ventricular tachycardia, can lead to the loss of consciousness and cardiac arrest followed by biological death. Note=Increased susceptibility to sudden cardiac death may be conferred by AKAP10 variants that are associated with markers of low vagus nerve sensitivity, e.g. fast basal heart rate and low heart rate variability.
  • Sequence similaritiesContains 2 RGS domains.
  • DomainRII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.
  • Cellular localizationMitochondrion. Membrane. Cytoplasm. Predominantly mitochondrial but also membrane associated and cytoplasmic.
  • Information by UniProt

References for Human AKAP10 peptide (ab45572)

ab45572 has not yet been referenced specifically in any publications.

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