Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceC-KQERESAKSELTES
    • Amino acids1769 to 1782

Specifications

Our Abpromise guarantee covers the use of ab23159 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General info

  • Alternative names
    • A kinase (PRKA) anchor protein (gravin) 12
    • A kinase Anchor Protein 12
    • A kinase Anchor Protein 12
    • A kinase anchor protein 250kDa
    • A-kinase anchor protein 12
    • A-kinase anchor protein 250 kDa
    • AKA12_HUMAN
    • AKAP 12
    • AKAP 250
    • AKAP-12
    • AKAP12
    • AKAP250
    • DKFZp686M0430
    • DKFZp686O0331
    • FLJ20945
    • FLJ97621
    • Gercelin
    • Gravin
    • Kinase scaffold protein gravin
    • Myasthenia gravis autoantigen
    • Myasthenia gravis autoantigen gravin
    • OTTHUMP00000017426
    • OTTHUMP00000017427
    • Src-Suppressed C Kinase Substrate
    • Srcs5
    • SSeCKS
    • Tsga12
    see all
  • FunctionAnchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC).
  • Tissue specificityExpressed in endothelial cells, cultured fibroblasts and osteosarcoma, but not in platelets, leukocytes, monocytic cell lines or peripherical blood cells.
  • Sequence similaritiesContains 3 AKAP domains.
  • DomainPolybasic regions located between residues 266 and 557 are involved in binding PKC.
  • Post-translational
    modifications
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localizationCytoplasm > cell cortex. Cytoplasm > cytoskeleton. May be part of the cortical cytoskeleton.
  • Target information above from: UniProt accession Q02952 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

References for Human AKAP12 peptide (ab23159)

ab23159 has not yet been referenced specifically in any publications.

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