Human Aldolase intron 2 ChIP Primer and Probe Set (ab85773)

Overview

  • Product nameHuman Aldolase intron 2 ChIP Primer and Probe Set
  • Product overview

    Accession number: NM_184043.
    The HsALDOA primers and probe can be can be used to quantify a control locus in chromatin immunoprecipitation (ChIP) assays with chromatin prepared from human cells.

    ALDOA (Fructose-bisphosphate aldolase A) is a moderately expressed housekeeping gene. The primers and probe are located in intron 2, within 1 kb of the transcription start site. In most cell types, this locus is enriched with histone modifications associated with active gene transcription such as Histone H3 K9 acetylation (see image with ab4441). Whereas it shows low levels of histone modifications associated with silencing such as Histone H3 K9 tri methylation (see image with ab8898).

Properties

  • FunctionPlays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein.
  • PathwayCarbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.
  • Involvement in diseaseDefects in ALDOA are the cause of glycogen storage disease type 12 (GSD12) [MIM:611881]; also known as red cell aldolase deficiency. A metabolic disorder associated with increased hepatic glycogen and hemolytic anemia. It may lead to myopathy with exercise intolerance and rhabdomyolysis.
  • Sequence similaritiesBelongs to the class I fructose-bisphosphate aldolase family.
  • Information by UniProt
  • Alternative names
    • ALDA
    • Aldo1
    • ALDOA
    • ALDOA_HUMAN
    • Aldolase 1
    • Aldolase A
    • Aldolase A fructose bisphosphatase
    • Aldolase A fructose bisphosphate
    • FRUCTOALDOLASE A
    • Fructose 1 6 bisphosphate triosephosphate lyase
    • Fructose bisphosphate aldolase
    • Fructose bisphosphate aldolase A
    • FRUCTOSE-1,6-BISPHOSPHATE ALDOLASE A
    • Fructose-bisphosphate aldolase A
    • Fructose-bisphosphate aldolase A Muscle-type
    • GSD12
    • Lung cancer antigen NY LU 1
    • Lung cancer antigen NY-LU-1
    • MGC10942
    • MGC17716
    • MGC17767
    • Muscle type aldolase
    • Muscle-type aldolase
    • RNALDOG5
    see all

References for Human Aldolase intron 2 ChIP Primer and Probe Set (ab85773)

ab85773 has not yet been referenced specifically in any publications.

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