Human Alpha 1 microglobulin full length protein (ab96148)
- Product nameHuman Alpha 1 microglobulin full length proteinSee all Alpha 1 microglobulin proteins and peptides ...
- Amino Acid Sequence
- Molecular weight30 kDa
- Amino acids20 to 203
Our Abpromise guarantee covers the use of ab96148 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- Additional NotesStarting material tested and found negative for HIV I & II antibodies, Hepatitis B surface antigen, and Hepatitis C antibodies.
- Concentration information loading...
Preparation and Storage
- Stability and Storage
Store at +4°C.
Constituents: 0.02M Ammonium bicarbonate
(May contain traces of buffer salts)
- ReconstitutionReconstitution in phosphate buffer, pH >7.0 containing 0.15M NaCl is recommended.
- Alpha 1 microglobulin/bikunin precursor
- Alpha 1 microglycoprotein
- Alpha-1 microglycoprotein
- Complex-forming glycoprotein heterogeneous in charge
- Growth inhibiting protein 19
- Inter-alpha-trypsin inhibitor light chain
- Microglobulin (alpha 1)
- Protein AMBP
- Protein HC
- Uronic-acid-rich protein
- FunctionInter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization.
Trypstatin is a trypsin inhibitor.
- Tissue specificityExpressed by the liver and secreted in plasma. Alpha-1-microglobulin occurs in many physiological fluids including plasma, urine, and cerebrospinal fluid. Inter-alpha-trypsin inhibitor is present in plasma and urine.
- Sequence similaritiesIn the N-terminal section; belongs to the calycin superfamily. Lipocalin family.
Contains 2 BPTI/Kunitz inhibitor domains.
modificationsThe precursor is proteolytically processed into separately functioning proteins.
3-hydroxykynurenine, an oxidized tryptophan metabolite that is common in biological fluids, reacts with Cys-53, Lys-111, Lys-137, and Lys-149 to form heterogeneous polycyclic chromophores including hydroxanthommatin. The reaction by alpha-1-microglobulin is autocatalytic; the human protein forms chromophore even when expressed in insect and bacterial cells. The chromophore can react with accessible cysteines forming non-reducible thioether cross-links with other molecules of alpha-1-microglobulin or with other proteins such as Ig alpha-1 chain C region 'Cys-352'.
Heavy chains are interlinked with bikunin via a chondroitin 4-sulfate bridge to the their C-terminal aspartate.
Addition of glycosaminoglycan chondroitin sulfate, allows cross-linking between the different components.
- Cellular localizationSecreted.
References for Human Alpha 1 microglobulin full length protein (ab96148)
ab96148 has not yet been referenced specifically in any publications.