Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human

Associated products

Specifications

Our Abpromise guarantee covers the use of ab40461 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-AMPK alpha 1 antibody (ab3759)

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: 0.09% Sodium Azide
    Constituents: 0.1% BSA, Tris buffered saline

General Info

  • Alternative names
    • 5 AMP activated protein kinase alpha 1catalytic subunit
    • 5 AMP activated protein kinase catalytic alpha 1 chain
    • 5' AMP activated protein kinase catalytic subunit alpha 1
    • 5'-AMP-activated protein kinase catalytic subunit alpha-1
    • AAPK1
    • AAPK1_HUMAN
    • ACACA kinase
    • acetyl CoA carboxylase kinase
    • AI194361
    • AI450832
    • AL024255
    • AMP -activate kinase alpha 1 subunit
    • AMP-activated protein kinase, catalytic, alpha -1
    • AMPK
    • AMPK 1
    • AMPK alpha 1
    • AMPK alpha 1 chain
    • AMPK subunit alpha-1
    • AMPK1
    • AMPKa1
    • AMPKalpha1
    • C130083N04Rik
    • cb116
    • EC 2.7.11.1
    • HMG CoA reductase kinase
    • HMGCR kinase
    • hormone sensitive lipase kinase
    • Hydroxymethylglutaryl CoA reductase kinase
    • im:7154392
    • kinase AMPK alpha1
    • MGC33776
    • MGC57364
    • OTTHUMP00000161795
    • OTTHUMP00000161796
    • PRKAA 1
    • PRKAA1
    • Protein kinase AMP activated alpha 1 catalytic subunit
    • SNF1-like protein AMPK
    • SNF1A
    • Tau protein kinase PRKAA1
    • wu:fa94c10
    see all
  • Function
    Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit.
  • Sequence similarities
    Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
    Contains 1 protein kinase domain.
  • Information by UniProt

References

ab40461 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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