The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-AMPK alpha 1 antibody (ab3759)
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Preservative: 0.09% Sodium Azide
Constituents: 0.1% BSA, Tris buffered saline
5 AMP activated protein kinase alpha 1catalytic subunit
5 AMP activated protein kinase catalytic alpha 1 chain
5' AMP activated protein kinase catalytic subunit alpha 1
5'-AMP-activated protein kinase catalytic subunit alpha-1
acetyl CoA carboxylase kinase
AMP -activate kinase alpha 1 subunit
AMP-activated protein kinase, catalytic, alpha -1
AMPK alpha 1
AMPK alpha 1 chain
AMPK subunit alpha-1
HMG CoA reductase kinase
hormone sensitive lipase kinase
Hydroxymethylglutaryl CoA reductase kinase
kinase AMPK alpha1
Protein kinase AMP activated alpha 1 catalytic subunit
SNF1-like protein AMPK
Tau protein kinase PRKAA1
FunctionResponsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit.
Sequence similaritiesBelongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. Contains 1 protein kinase domain.