Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      STVHEILCKLSLEGD
    • Amino acids
      2 to 16

Associated products

Specifications

Our Abpromise guarantee covers the use of ab22880 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-Annexin A2 antibody (ab2242)

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • Annexin A2
    • Annexin II
    • Annexin II, heavy chain
    • Annexin-2
    • ANX 2
    • ANX2
    • ANX2L4
    • ANXA2
    • ANXA2_HUMAN
    • arylsulfatase B
    • CAL1H
    • Calpactin I heavy chain
    • Calpactin I heavy polypeptide
    • calpactin I heavy polypeptide (p36)
    • Calpactin-1 heavy chain
    • chromobindin 8
    • Chromobindin-8
    • Epididymis secretory protein Li 270
    • HEL S 270
    • LIP2
    • Lipocortin II
    • LPC2
    • LPC2D
    • p36
    • P36 protein
    • PAP-IV
    • Placental anticoagulant protein IV
    • Protein I
    see all
  • Function
    Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response.
  • Sequence similarities
    Belongs to the annexin family.
    Contains 4 annexin repeats.
  • Domain
    A pair of annexin repeats may form one binding site for calcium and phospholipid.
  • Post-translational
    modifications
    Phosphorylation of Tyr-24 enhances heat stress-induced translocation to the cell surface.
    ISGylated.
  • Cellular localization
    Secreted > extracellular space > extracellular matrix > basement membrane. Melanosome. In the lamina beneath the plasma membrane. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Translocated from the cytoplasm to the cell surface through a Golgi-independent mechanism.
  • Information by UniProt

References

ab22880 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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