Human Anthrax EF peptide (ab41848)
- Product nameHuman Anthrax EF peptide
- Amino Acid Sequence
- Amino acids0 to 0
Our Abpromise guarantee covers the use of ab41848 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Preparation and Storage
- Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Preservative: 0.02% Sodium Azide
Constituents: 0.1% BSA, PBS, pH 7.2
- Adenylyl cyclase
- Anthrax edema toxin adenylate cyclase component
- ATP pyrophosphate lyase
- Bacillus anthracis EF
- Calmodulin sensitive adenylate cyclase
- Edema factor
- RelevanceAnthrax infection is initiated by inhalation, ingestion or cutaneous contact with Bacillus anthracis endospores. B. anthracis produces three polypeptides that comprise the anthrax toxin: protective antigen (PA), lethal factor (LF) and edema factor (EF). PA binds to two related proteins on the cell surface; these are termed tumor epithelial marker 8 (TEM8)/anthrax toxin receptor (ATR) and capillary morphogenesis protein 2 (CMG2), although it is still unclear which is physiologically relevant. Following PA binding to its receptor, PA is cleaved into two fragments by a furin like protease. The bound fragment binds both LF and EF; the resulting complex is then endocytosed which allows the translocation of LF and EF into the cytoplasm. EF is a calmodulin and Ca++ dependent adenylate cyclase responsible for the edema seen in the disease. It is thought to benefit the B. anthracis bacteria by inhibiting cells of the host immune system.
References for Human Anthrax EF peptide (ab41848)
ab41848 has not yet been referenced specifically in any publications.