Human Apolipoprotein CIII full length protein (ab77944)

Overview

Description

  • NatureNatural
  • SourceNative
  • Amino Acid Sequence
    • SpeciesHuman
    • Amino acids0 to 0

Specifications

Our Abpromise guarantee covers the use of ab77944 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    SDS-PAGE

  • Purity> 95 % by SDS-PAGE.

  • FormLyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 10mM Ammonium bicarbonate, pH 7.4

  • ReconstitutionReconstitute with 59.9ul distilled water.

General info

  • Alternative names
    • APOC3
    • APO C3
    • Apo CIII
    • Apo-CIII
    • APOC 3
    • ApoC III
    • ApoC-III
    • APOC3
    • APOC3_HUMAN
    • ApoCIII
    • Apolipoprotein C III
    • Apolipoprotein C-III
    • Apolipoprotein C3
    • ApolipoproteinCIII
    • MGC150353
    see all
  • FunctionInhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. This suggests that it delays the catabolism of triglyceride-rich particles.
  • Tissue specificityConstitutes 50% of the protein fraction of VLDL and 2% of that of HDL. Synthesized predominantly in liver and to a lesser degree in intestine.
  • Involvement in diseaseDefects in APOC3 may be a cause of hyperalphalipoproteinemia (HYPALIP) [MIM:143470]. Affected individuals show high levels of alpha-lipoprotein (high density lipoprotein/HDL).
  • Sequence similaritiesBelongs to the apolipoprotein C3 family.
  • Post-translational
    modifications
    O-linked glycan consists of Gal-GalNAc disaccharide, further modified with up to 3 sialic acid residues. O-glycosylated on Thr-94 with a core 1 or possibly core 8 glycan.
  • Cellular localizationSecreted.
  • Target information above from: UniProt accession P02656 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

Human Apolipoprotein CIII full length protein images

  • All lanes : Anti-Apolipoprotein CIII antibody (ab21032) at 1 µg/ml

    Lane 1 : Human Apolipoprotein CIII full length protein (ab77944) at 0.1 µg
    Lane 2 : Human Apolipoprotein CIII full length protein (ab77944) at 0.01 µg

    Secondary
    Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilution
    developed using the ECL technique

    Performed under reducing conditions.

    Exposure time : 1 minute

References for Human Apolipoprotein CIII full length protein (ab77944)

ab77944 has not yet been referenced specifically in any publications.

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