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Human APPL peptide
Amino Acid Sequence
697 to 703
Our Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
- Adapter protein containing PH domain
- Adaptor Protein Containing pH Domain
- Adaptor protein containing pH domain PTB domain and leucine zipper motif
Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction.
High levels in heart, ovary, pancreas and skeletal muscle.
Contains 1 PH domain.
Contains 1 PID domain.
Overexpression of an N-terminal domain (residues 1-319) or a C-terminal region (residues 273-709) has a proapoptotic effect.
Phosphorylated upon DNA damage, probably by ATM or ATR.
Early endosome membrane. Nucleus. Early endosomal membrane-bound and nuclear. Translocated into the nucleus upon release from endosomal membranes following internalization of EGF.
Information by UniProt
References for Human APPL peptide (ab23103)
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"