Overview

  • Product nameHuman APPL peptide

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceC-DLGEGGKKRESEA
    • Amino acids697 to 703

Specifications

Our Abpromise guarantee covers the use of ab23103 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • Adapter protein containing PH domain
    • Adaptor Protein Containing pH Domain
    • Adaptor protein containing pH domain PTB domain and leucine zipper motif
    • Adaptor protein containing pH domain PTB domain and leucine zipper motif 1
    • AKT2 INTERACTOR
    • APPL 1
    • Appl1
    • DCC interacting protein 13 alpha
    • DCC-interacting protein 13-alpha
    • DIP 13 alpha
    • DIP13 alpha
    • Dip13-alpha
    • DIP13alpha
    • DP13A_HUMAN
    • KIAA1428
    • PTB Domain and Leucine Zipper Motif
    • PTB domain and leucine zipper motif 1
    • Signaling adaptor protein DIP13alpha
    see all
  • FunctionRequired for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction.
  • Tissue specificityHigh levels in heart, ovary, pancreas and skeletal muscle.
  • Sequence similaritiesContains 1 PH domain.
    Contains 1 PID domain.
  • DomainOverexpression of an N-terminal domain (residues 1-319) or a C-terminal region (residues 273-709) has a proapoptotic effect.
  • Post-translational
    modifications
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localizationEarly endosome membrane. Nucleus. Early endosomal membrane-bound and nuclear. Translocated into the nucleus upon release from endosomal membranes following internalization of EGF.
  • Information by UniProt

References for Human APPL peptide (ab23103)

ab23103 has not yet been referenced specifically in any publications.

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