Overview

  • Product name
    Human APPL peptide

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      C-DLGEGGKKRESEA
    • Amino acids
      697 to 703

Specifications

Our Abpromise guarantee covers the use of ab23103 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • Adapter protein containing PH domain
    • Adaptor Protein Containing pH Domain
    • Adaptor protein containing pH domain PTB domain and leucine zipper motif
    • Adaptor protein containing pH domain PTB domain and leucine zipper motif 1
    • Adaptor protein phosphotyrosine interacting with PH domain and leucine zipper 1
    • AKT2 INTERACTOR
    • APPL 1
    • Appl1
    • DCC interacting protein 13 alpha
    • DCC-interacting protein 13-alpha
    • DIP 13 alpha
    • DIP13 alpha
    • Dip13-alpha
    • DIP13alpha
    • DP13A_HUMAN
    • KIAA1428
    • PTB Domain and Leucine Zipper Motif
    • PTB domain and leucine zipper motif 1
    • Signaling adaptor protein DIP13alpha
    see all
  • Function
    Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction.
  • Tissue specificity
    High levels in heart, ovary, pancreas and skeletal muscle.
  • Sequence similarities
    Contains 1 PH domain.
    Contains 1 PID domain.
  • Domain
    Overexpression of an N-terminal domain (residues 1-319) or a C-terminal region (residues 273-709) has a proapoptotic effect.
  • Post-translational
    modifications
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localization
    Early endosome membrane. Nucleus. Early endosomal membrane-bound and nuclear. Translocated into the nucleus upon release from endosomal membranes following internalization of EGF.
  • Information by UniProt

References

ab23103 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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