Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceC-AFTADPLSLLRNV
    • Amino acids1198 to 1210

Associated products

Specifications

Our Abpromise guarantee covers the use of ab23119 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-ARAP1 antibody (ab5912)

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • 2410002L19Rik
    • ANK repeat and PH domain-containing protein 1
    • ARAP 1
    • Arap1
    • ARAP1_HUMAN
    • Arf GAP Rho GAP ankyrin repeat and pleckstrin homology domains containing protein 1
    • Arf GAP Rho GAP ankyrin repeat and pleckstrin homology domain containing protein 1
    • Arf-GAP with Rho-GAP domain
    • CENT D2
    • Centaurin delta 2
    • Centaurin delta2
    • Centaurin-delta-2
    • CENTD 2
    • CENTD2
    • Cnt d2
    • Cnt-d2
    • Cntd2
    • KIAA0782
    • MGC176140
    • mKIAA0782
    see all
  • FunctionPhosphatidylinositol-3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol-3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Has a preference for ARF1 and ARF5.
  • Tissue specificityDetected in heart, skeletal muscle, spleen, kidney, liver, placenta, lung, peripheral blood leukocytes, adrenal gland, bone marrow, brain, lymph node, mammary gland, prostate, spinal cord, stomach, thyroid and trachea.
  • Sequence similaritiesContains 1 Arf-GAP domain.
    Contains 4 PH domains.
    Contains 1 Ras-associating domain.
    Contains 1 Rho-GAP domain.
    Contains 1 SAM (sterile alpha motif) domain.
  • Cellular localizationCytoplasm. Golgi apparatus > Golgi stack membrane. Cell membrane. Associated with Golgi stacks in resting cells. Throughout the cytoplasm and in surface protrusion in cells that are in the process of attaching to a surface and spreading.
  • Information by UniProt

References for Human ARAP1 peptide (ab23119)

ab23119 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"