Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      C-AFTADPLSLLRNV
    • Amino acids
      1198 to 1210

Associated products

Specifications

Our Abpromise guarantee covers the use of ab23119 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-ARAP1 antibody (ab5912)

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • 2410002L19Rik
    • ANK repeat and PH domain-containing protein 1
    • ARAP 1
    • Arap1
    • ARAP1_HUMAN
    • Arf GAP Rho GAP ankyrin repeat and pleckstrin homology domains containing protein 1
    • Arf GAP Rho GAP ankyrin repeat and pleckstrin homology domain containing protein 1
    • Arf-GAP with Rho-GAP domain
    • CENT D2
    • Centaurin delta 2
    • Centaurin delta2
    • Centaurin-delta-2
    • CENTD 2
    • CENTD2
    • Cnt d2
    • Cnt-d2
    • Cntd2
    • KIAA0782
    • MGC176140
    • mKIAA0782
    see all
  • Function
    Phosphatidylinositol-3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol-3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Has a preference for ARF1 and ARF5.
  • Tissue specificity
    Detected in heart, skeletal muscle, spleen, kidney, liver, placenta, lung, peripheral blood leukocytes, adrenal gland, bone marrow, brain, lymph node, mammary gland, prostate, spinal cord, stomach, thyroid and trachea.
  • Sequence similarities
    Contains 1 Arf-GAP domain.
    Contains 4 PH domains.
    Contains 1 Ras-associating domain.
    Contains 1 Rho-GAP domain.
    Contains 1 SAM (sterile alpha motif) domain.
  • Cellular localization
    Cytoplasm. Golgi apparatus > Golgi stack membrane. Cell membrane. Associated with Golgi stacks in resting cells. Throughout the cytoplasm and in surface protrusion in cells that are in the process of attaching to a surface and spreading.
  • Information by UniProt

References for Human ARAP1 peptide (ab23119)

ab23119 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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