Human Asialoglycoprotein Receptor 1 peptide (ab98248)

Overview

Description

  • NatureSynthetic

Associated products

Specifications

Our Abpromise guarantee covers the use of ab98248 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Purity70 - 90% by HPLC.

  • FormLiquid
  • Additional notes

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

General Info

  • Alternative names
    • ASGP-R 1
    • ASGPR
    • ASGPR 1
    • ASGPR1
    • Asgr1
    • ASGR1_HUMAN
    • Asialoglycoprotein receptor 1
    • C type lectin domain family 4 member H1
    • C-type lectin domain family 4 member H1
    • CLEC4H1
    • Hepatic lectin H1
    • HL-1
    see all
  • FunctionMediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.
  • Tissue specificityExpressed exclusively in hepatic parenchymal cells.
  • Sequence similaritiesContains 1 C-type lectin domain.
  • Post-translational
    modifications
    Phosphorylated on a cytoplasmic Ser residue.
  • Cellular localizationMembrane.
  • Information by UniProt

References for Human Asialoglycoprotein Receptor 1 peptide (ab98248)

ab98248 has not yet been referenced specifically in any publications.

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