Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      C-QNKESASKQS
    • Amino acids
      394 to 403

Specifications

Our Abpromise guarantee covers the use of ab23157 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • AIK
    • ARK-1
    • ARK1
    • AURA
    • Aurka
    • Aurora 2
    • Aurora A
    • Aurora kinase A
    • Aurora-related kinase 1
    • Aurora/IPL1 like kinase
    • Aurora/IPL1-related kinase 1
    • AURORA2
    • Breast tumor-amplified kinase
    • BTAK
    • hARK1
    • IAK
    • IPL1 related kinase
    • MGC34538
    • OTTHUMP00000031340
    • OTTHUMP00000031341
    • OTTHUMP00000031342
    • OTTHUMP00000031343
    • OTTHUMP00000031344
    • OTTHUMP00000031345
    • OTTHUMP00000166071
    • OTTHUMP00000166072
    • PPP1R47
    • Protein phosphatase 1, regulatory subunit 47
    • Serine/threonine kinase 15
    • Serine/threonine kinase 6
    • Serine/threonine-protein kinase 15
    • Serine/threonine-protein kinase 6
    • Serine/threonine-protein kinase aurora-A
    • STK15
    • STK6
    • STK6_HUMAN
    • STK7
    see all
  • Function
    Contributes to the regulation of cell cycle progression. Required for normal mitosis. Associates with the centrosome and the spindle microtubules during mitosis and functions in centrosome maturation, spindle assembly, maintenance of spindle bipolarity, centrosome separation and mitotic checkpoint control. Phosphorylates numerous target proteins, including ARHGEF2, BRCA1, KIF2A, NDEL1, PARD3, PLK1 and BORA. Regulates KIF2A tubulin depolymerase activity (By similarity). Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization.
  • Tissue specificity
    Highly expressed in testis and weakly in skeletal muscle, thymus and spleen. Also highly expressed in colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell lines.
  • Sequence similarities
    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
    Contains 1 protein kinase domain.
  • Post-translational
    modifications
    Activated by phosphorylation at Thr-288; this brings about a change in the conformation of the activation segment. Phosphorylation at Thr-288 varies during the cell cycle and is highest during M phase. Autophosphorylated at Thr-288 upon TPX2 binding. Phosphorylated upon DNA damage, probably by ATM or ATR.
    Ubiquitinated by CHFR, leading to its degradation by the proteasome (By similarity). Ubiquitinated by the anaphase-promoting complex (APC), leading to its degradation by the proteasome.
  • Cellular localization
    Cytoplasm > cytoskeleton > centrosome. Cytoplasm > cytoskeleton > spindle pole. Detected at the neurite hillock in developing neurons (By similarity). Localizes on centrosomes in interphase cells and at each spindle pole in mitosis.
  • Information by UniProt

References

ab23157 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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