Human Azurocidin full length protein (ab91129)

Overview

Description

  • NatureNatural
  • SourceNative
  • Amino Acid Sequence
    • SpeciesHuman
    • Amino acids0 to 0

Specifications

Our Abpromise guarantee covers the use of ab91129 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    SDS-PAGE

  • Purity> 95 % by SDS-PAGE.

  • FormLyophilised
  • Additional NotesPrepared from whole blood shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

    De-ionized H2O

General info

  • Alternative names
    • Azu 1
    • Azu1
    • Azurocidin
    • CAP37
    • CAP7_HUMAN
    • cationic antimicrobial protein 37
    • Cationic antimicrobial protein CAP37
    • HBP
    • Heparin binding protein
    • Heparin-binding protein
    • HUMAZUR
    • Neutrophil azurocidin
    see all
  • FunctionThis is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in mediating recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Acting alone, it does not have antimicrobial activity against the Gram-negative bacteria A.actinomycetemcomitans ATCC 29532, A.actinomycetemcomitans NCTC 9709, A.actinomycetemcomitans FDC-Y4, H.aphrophilus ATCC 13252, E.corrodens ATCC 23834, C.sputigena ATCC 33123, Capnocytophaga sp ATCC 33124, Capnocytophaga sp ATCC 27872 or E.coli ML-35. Has antibacterial activity against C.sputigena ATCC 33123 when acting synergistically with either elastase or cathepsin G.
  • Sequence similaritiesBelongs to the peptidase S1 family. Elastase subfamily.
    Contains 1 peptidase S1 domain.
  • Cellular localizationCytoplasmic granule. Cytoplasmic granules of neutrophils.
  • Information by UniProt

Human Azurocidin full length protein images

  • Anti-Azurocidin antibody (ab48132) at 1 µg/ml + Human Azurocidin full length protein (ab91129) at 0.1 µg

    Secondary
    Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilution
    developed using the ECL technique

    Performed under reducing conditions.

    Exposure time : 2 minutes
  • Lane 1. LMW Standard
    Lane 2. Azurocidin - 5 µg (reduced / heated)
    Lane 3. Azurocidin - 10 µg (reduced / heated)
    Lane 4. Azurocidin - 20 µg (reduced / heated)
    4-12% Bis-Tris SDS-PAGE gel

References for Human Azurocidin full length protein (ab91129)

ab91129 has not yet been referenced specifically in any publications.

Product Wall

Thank you for contacting us. This protein is lyophilised from de-ionized water, and reconstituted to pre-lyophilisation volume with de-ionized water. I hope this information is helpful to you. Please do not hesitate to contact us if you ...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"