The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-BACE1 antibody (ab10716)
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
APP beta secretase
Aspartyl protease 2
Beta secretase 1
Beta site amyloid beta A4 precursor protein cleaving enzyme
Beta site amyloid precursor protein cleaving enzyme
Beta site amyloid precursor protein cleaving enzyme 1
Beta site APP cleaving enzyme
Beta site APP cleaving enzyme 1
Beta-site amyloid precursor protein cleaving enzyme 1
Beta-site APP cleaving enzyme 1
Membrane associated aspartic protease 2
Membrane-associated aspartic protease 2
Transmembrane aspartic proteinase Asp2
FunctionResponsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.
Tissue specificityExpressed at high levels in the brain and pancreas. In the brain, expression is highest in the substantia nigra, locus coruleus and medulla oblongata.
Sequence similaritiesBelongs to the peptidase A1 family.
DomainThe transmembrane domain is necessary for its activity. It determines its late Golgi localization and access to its substrate, APP.
Cellular localizationMembrane. Golgi apparatus > trans-Golgi network. Endoplasmic reticulum. Endosome. Cell surface. Predominantly localized to the later Golgi/trans-Golgi network (TGN) and minimally detectable in the early Golgi compartments. A small portion is also found in the endoplasmic reticulum, endosomes and on the cell surface.