Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceC-SSMTDTPGNPAAP
    • Amino acids563 to 575

Associated products

Specifications

Our Abpromise guarantee covers the use of ab23111 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-Bag3 antibody (ab5898)

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • BAG 3
    • BAG family molecular chaperone regulator 3
    • BAG-3
    • Bag3
    • BAG3_HUMAN
    • Bcl 2 binding protein
    • Bcl-2-associated athanogene 3
    • Bcl-2-binding protein Bis
    • BCL2 associated athanogene 3
    • BCL2 binding athanogene 3
    • BIS
    • CAIR 1
    • Docking protein CAIR 1
    • Docking protein CAIR-1
    • MFM6
    see all
  • FunctionInhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity.
  • Involvement in diseaseDefects in BAG3 are the cause of myopathy myofibrillar BAG3-related (MFM-BAG3) [MIM:612954]. A neuromuscular disorder that results in early-onset, severe, progressive, diffuse muscle weakness associated with cardiomyopathy, severe respiratory insufficiency during adolescence, and a rigid spine in some patients. At ultrastructural level, muscle fibers display structural alterations consisting of replacement of the normal myofibrillar markings by small, dense granules, or larger hyaline masses, or amorphous material.
  • Sequence similaritiesContains 1 BAG domain.
    Contains 2 WW domains.
  • Information by UniProt

References for Human Bag3 peptide (ab23111)

ab23111 has not yet been referenced specifically in any publications.

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