Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • AccessionQ07817
    • SpeciesHuman

Specifications

Our Abpromise guarantee covers the use of ab39728 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    Blocking

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: 0.02% Sodium Azide
    Constituents: PBS, 0.1% bovine serum albumin, pH 7.2

General Info

  • Alternative names
    • Apoptosis regulator Bcl X
    • Apoptosis regulator Bcl-X
    • Apoptosis regulator BclX
    • B cell lymphoma 2 like
    • B2CL1_HUMAN
    • Bcl 2 like 1 protein
    • Bcl X
    • Bcl xL
    • BCL XL/S
    • Bcl xS
    • Bcl-2-like protein 1
    • Bcl2 Like 1
    • Bcl2 related gene
    • Bcl2-L-1
    • BCL2L
    • Bcl2l1
    • BCLX
    • BclXL
    • BclXs
    • DKFZp781P2092
    • PPP1R52
    • Protein phosphatase 1 regulatory subunit 52
    see all
  • FunctionPotent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channnel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane.
    Isoform Bcl-X(S) promotes apoptosis.
  • Tissue specificityBcl-X(S) is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, Bcl-X(L) is found in tissues containing long-lived postmitotic cells, such as adult brain.
  • Sequence similaritiesBelongs to the Bcl-2 family.
  • DomainThe BH4 motif is required for anti-apoptotic activity. The BH1 and BH2 motifs are required for both heterodimerization with other Bcl-2 family members and for repression of cell death.
  • Post-translational
    modifications
    Proteolytically cleaved by caspases during apoptosis. The cleaved protein, lacking the BH4 motif, has pro-apoptotic activity.
  • Cellular localizationMitochondrion membrane. Nucleus membrane. Mitochondrial membranes and perinuclear envelope.
  • Information by UniProt

References for Human Bcl-XL peptide (ab39728)

ab39728 has not yet been referenced specifically in any publications.

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