Overview

Description

  • NatureSynthetic

Associated products

Specifications

Our Abpromise guarantee covers the use of ab97495 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Purity70 - 90% by HPLC.

  • FormLiquid
  • Additional notes

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

General Info

  • Alternative names
    • B cell CLL/lymphoma 6
    • B cell lymphoma 6 protein
    • B-cell lymphoma 5 protein
    • B-cell lymphoma 6 protein
    • BCL 5
    • Bcl 6
    • BCL-5
    • BCL-6
    • BCL5
    • BCL6
    • BCL6_HUMAN
    • BCL6A
    • cys his2 zinc finger transcription factor
    • LAZ 3
    • LAZ 3 protein
    • LAZ3
    • Lymphoma associated zinc finger gene on chromosome 3
    • Protein LAZ-3
    • ZBTB 27
    • ZBTB27
    • Zinc finger and BTB domain containing protein 27
    • Zinc finger and BTB domain-containing protein 27
    • Zinc finger protein 51
    • zinc finger transcription factor BCL6S
    • ZNF 51
    • ZNF51
    see all
  • FunctionTranscriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.
  • Tissue specificityExpressed in germinal center T and B cells and in primary immature dendritic cells.
  • Involvement in diseaseNote=Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions.
    Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1.
    Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF.
  • Sequence similaritiesContains 1 BTB (POZ) domain.
    Contains 6 C2H2-type zinc fingers.
  • DomainThe BTB domain mediates homodimerization. Its dimer interface mediates peptide binding such as to corepressors BCOR and NCOR2.
  • Post-translational
    modifications
    Phosphorylated by MAPK1 in response to antigen receptor activation. Phosphorylation induces its degradation by ubiquitin/proteasome pathway.
  • Cellular localizationNucleus.
  • Information by UniProt

References for Human Bcl6 peptide (ab97495)

ab97495 has not yet been referenced specifically in any publications.

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