Human BIN1 protein fragment (ab91662)
- Product nameHuman BIN1 protein fragmentSee all BIN1 proteins and peptides ...
- SourceE. coli
- Amino Acid Sequence
- SequenceGRDEANKIAENNDLLWMDYHQKLVDQALLTMDTYLGQFPD IKSRIAKRGRK LVDYDSARHHYESLQTAKKKDEAKIAK AEEELIKAQKVFEEMNVDLQEEL PSLWNSRVGFYVNTF QSIAGLEENFHKEMSKLNQNLNDVLVGLEKQHGSN TFT VKAQPSDNAPAKGNKSPSPPDGSPAATPEIRVNHEPEPAG GATPGAT LPKSPSQPAEASEVAGGTQPAAGAQEPGETA ASEAASSSLPAVVVETFPA TVNGTVEGGSGAGRLDLPP GFMFKVQAQHDYTATDTDELQLKAGDVVLVI PFQNPEE QDEGWLMGVKESDWNQHKELEKCRGVFPENFTERVP
- Amino acids96 to 439
Our Abpromise guarantee covers the use of ab91662 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- Concentration information loading...
Preparation and Storage
- Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
Constituents: 0.5% Trehalose, 6M Urea, 100mM Sodium hydrogen phosphate, 10mM Sodium chloride, pH 4.5
- ReconstitutionReconstitute with 118 µl aqua dest
- AMPH 2
- Amphiphysin 2
- Amphiphysin II
- Amphiphysin like protein
- Amphiphysin-like protein
- Box Dependant MYC Interacting Protein 1
- Box-dependent myc-interacting protein 1
- Bridging Integrator 1
- Myc box dependent interacting protein 1
- Myc box-dependent-interacting protein 1
- FunctionMay be involved in regulation of synaptic vesicle endocytosis. May act as a tumor suppressor and inhibits malignant cell transformation.
- Tissue specificityUbiquitous. Highest expression in the brain and muscle. Isoform IIA is expressed only in the brain where it is concentrated in axon initial segments and nodes of Ranvier. Isoform BIN1 is widely expressed with highest expression in skeletal muscle.
- Involvement in diseaseDefects in BIN1 are the cause of centronuclear myopathy autosomal recessive (ARCNM) [MIM:255200]; also known as autosomal recessive myotubular myopathy. Centronuclear myopathies are congenital muscle disorders characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers.
- Sequence similaritiesContains 1 BAR domain.
Contains 1 SH3 domain.
modificationsPhosphorylated by protein kinase C.
- Cellular localizationCytoplasm and Nucleus.
References for Human BIN1 protein fragment (ab91662)
ab91662 has not yet been referenced specifically in any publications.