Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      C-KDSTRLKYAVKVS
    • Amino acids
      444 to 456

Associated products

Specifications

Our Abpromise guarantee covers the use of ab22871 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-BLNK antibody (ab2230)

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • AGM4
    • B cell adapter containing SH2 domain protein
    • B cell adapter containing Src homology 2 domain protein
    • B cell adaptor containing SH2 domain
    • B cell linker
    • B cell linker protein
    • B cell-specific adaptor protein
    • B-cell activation
    • B-cell adapter containing a SH2 domain protein
    • B-cell adapter containing a Src homology 2 domain protein
    • B-cell linker protein
    • BASH
    • Bca
    • BLNK
    • BLNK s
    • BLNK_HUMAN
    • Cytoplasmic adapter protein
    • Ly 57
    • Ly57
    • Lymphocyte antigen 57
    • Lyw 57
    • Lyw57
    • MGC111051
    • SH2 domain-containing leukocyte protein, 65-KD
    • SLP 65
    • SLP-65
    • SLP65
    • Src homology [SH2] domain-containing leukocyte protein of 65 kD
    • Src homology 2 domain containing leukocyte protein of 65 kDa
    • Src homology 2 domain-containing leukocyte protein of 65 kDa
    see all
  • Function
    Functions as a central linker protein that bridges kinases associated with the B-cell receptor (BCR) with a multitude of signaling pathways, regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition (By similarity). Plays an important role in BCR-induced B-cell apoptosis.
  • Tissue specificity
    Expressed in B-cell lineage and fibroblast cell lines (at protein level). Highest levels of expression in the spleen, with lower levels in the liver, kidney, pancreas, small intestines and colon.
  • Involvement in disease
    Defects in BLNK are the cause of agammaglobulinemia type 4 (AGM4) [MIM:613502]. It is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life.
  • Sequence similarities
    Contains 1 SH2 domain.
  • Post-translational
    modifications
    Following BCR activation, phosphorylated on tyrosine residues by SYK and LYN. When phosphorylated, serves as a scaffold to assemble downstream targets of antigen activation, including PLCG1, VAV1, GRB2 and NCK1. Phosphorylation of Tyr-84, Tyr-178 and Tyr-189 facilitates PLCG1 binding. Phosphorylation of Tyr-96 facilitates BTK binding. Phosphorylation of Tyr-72 facilitates VAV1 and NCK1 binding. Phosphorylation is required for both Ca(2+) and MAPK signaling pathways.
  • Cellular localization
    Cytoplasm. Cell membrane. BCR activation results in the translocation to membrane fraction.
  • Information by UniProt

References

ab22871 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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