Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman

Associated products

Specifications

Our Abpromise guarantee covers the use of ab39733 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

    Western blot

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: 0.02% Sodium Azide
    Constituents: PBS, 0.1% bovine serum albumin, pH 7.2

General Info

  • Alternative names
    • B lymphoma Mo MLV insertion region (mouse)
    • B lymphoma Mo MLV insertion region 1 homolog
    • Bmi 1
    • BMI1
    • BMI1 polycomb ring finger oncogene
    • BMI1_HUMAN
    • Flvi 2/bmi 1
    • FLVI2/BMI1
    • MGC12685
    • Murine leukemia viral (bmi 1) oncogene homolog
    • Oncogene BMI 1
    • PCGF 4
    • PCGF4
    • Polycomb complex protein BMI 1
    • Polycomb complex protein BMI-1
    • Polycomb group protein Bmi1
    • Polycomb group ring finger 4
    • Polycomb group RING finger protein 4
    • RING finger protein 51
    • RNF 51
    • RNF51
    see all
  • FunctionComponent of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.
  • Sequence similaritiesContains 1 RING-type zinc finger.
  • Post-translational
    modifications
    Monoubiquitinated (By similarity). May be polyubiquitinated; which does not lead to proteasomal degradation.
  • Cellular localizationNucleus. Cytoplasm.
  • Information by UniProt

References for Human Bmi1 peptide (ab39733)

ab39733 has not yet been referenced specifically in any publications.

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