Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceSPKMVQGSGC(G)
    • Amino acids1 to 10

Specifications

Our Abpromise guarantee covers the use of ab42276 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Purity> 95 % SDS-PAGE.

  • FormLyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. After reconstitution store at -20ºC. Avoid freeze / thaw cycles.

  • ReconstitutionResuspend in 1 ml 0.1% acetic acid

General Info

  • Alternative names
    • BNP(1-28)
    • BNP(1-29)
    • BNP(1-30)
    • BNP(1-32)
    • BNP(2-31)
    • BNP(3-29)
    • BNP(3-30)
    • BNP(3-32)
    • BNP(4-27)
    • BNP(4-29)
    • BNP(4-30)
    • BNP(4-31)
    • BNP(4-32)
    • BNP(5-29)
    • BNP(5-31)
    • BNP(5-32)
    • Brain natriuretic peptide 32
    • Brain type natriuretic peptide
    • Gamma brain natriuretic peptide
    • Natriuretic peptide B
    • Natriuretic peptide precursor B
    • natriuretic peptide, brain type
    • Natriuretic peptides B
    • natriuretic protein
    • NPPB
    see all
  • RelevanceBrain natriuretic peptide (BNP) circulates in blood as a peptide hormone with natriuretic, vasodilatory and renin inhibitory properties. BNP is secreted predominantly by the left ventricular myocytes in response to volume expansion and pressure overload. BNP belongs to a family of structurally similar peptide hormones, which includes atrial natriuretic peptide (ANP), BNP, C type natriuretic peptide (CNP) and urodilatin. These peptides are characterized by a common 17 amino acid ring structure with a disulfide bond between two cystein residues. This ring structure shows high homology between different natriuretic peptides (eleven of the 17 amino acid residues are homologous in the ring of each of the natriuretic peptides). BNP is a 32 amino acid peptide with disulfide bond between the cysteine residues Cys10 and Cys26. In earlier studies it has been demonstrated that BNP concentration in blood increases with the severity of congestive heart failure. Quantitative measurement of BNP in blood provides an objective indicator of congestive heart failure severity.
  • Cellular localizationSecreted

References for Human BNP peptide (ab42276)

ab42276 has not yet been referenced specifically in any publications.

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