Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      C-DAYALNHTLSVEGF
    • Amino acids
      243 to 256

Associated products

Specifications

Our Abpromise guarantee covers the use of ab22946 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-BOB1 antibody (ab3426)

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • B cell Oct binding protein 1
    • B cell specific coactivator OBF 1
    • B cell specific coactivator OBF1
    • B-cell-specific coactivator OBF-1
    • BOB 1
    • BOB-1
    • OBF 1
    • OBF1
    • OBF1_HUMAN
    • OCA B
    • OCA-B
    • OCAB
    • OCT binding factor 1
    • OCT-binding factor 1
    • POU class 2 associating factor 1
    • POU domain class 2 associating factor 1
    • POU domain class 2-associating factor 1
    • Pou2af1
    see all
  • Function
    Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers.
  • Tissue specificity
    B-cell specific.
  • Involvement in disease
    Note=A chromosomal aberration involving POU2AF1/OBF1 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with BCL6.
  • Sequence similarities
    Belongs to the POU2AF1 family.
  • Post-translational
    modifications
    Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.
  • Cellular localization
    Nucleus.
  • Information by UniProt

References for Human BOB1 peptide (ab22946)

ab22946 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab22946.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up