Human Calpain 3 protein fragment (ab114577)
- Product nameHuman Calpain 3 protein fragmentSee all Calpain 3 proteins and peptides ...
- SourceWheat germ
- Amino Acid Sequence
- SequenceNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQ LYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDK DGDGIIKLNVLEWLQLTMYA
- Molecular weight37 kDa including tags
- Amino acids722 to 821
Our Abpromise guarantee covers the use of ab114577 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- Additional NotesProtein concentration is above or equal to 0.05 mg/ml.
This protein is best used within three months from the date of receipt.
- Concentration information loading...
Preparation and Storage
- Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
Constituents: 0.3% Glutathione, 0.79% Tris HCl
- Calcium-activated neutral proteinase 3
- calpain 3, (p94)
- Calpain L3
- Calpain large polypeptide L3
- Calpain p94
- calpain p94, large [catalytic] subunit
- calpain, large polypeptide L3
- CANP 3
- LGMD 2A
- Muscle-specific calcium-activated neutral protease 3
- muscle-specific calcium-activated neutral protease 3 large subunit
- New calpain 1
- FunctionCalcium-regulated non-lysosomal thiol-protease.
- Tissue specificityIsoform I is skeletal muscle specific.
- Involvement in diseaseDefects in CAPN3 are the cause of limb-girdle muscular dystrophy type 2A (LGMD2A) [MIM:253600]. LGMD2A is an autosomal recessive degenerative myopathy characterized by progressive symmetrical atrophy and weakness of the proximal limb muscles and elevated serum creatine kinase. The symptoms usually begin during the first two decades of life, and the disease gradually worsens, often resulting in loss of walking ability 10 or 20 years after onset.
- Sequence similaritiesBelongs to the peptidase C2 family.
Contains 1 calpain catalytic domain.
Contains 4 EF-hand domains.
- Cellular localizationCytoplasm.
References for Human Calpain 3 protein fragment (ab114577)
ab114577 has not yet been referenced specifically in any publications.