Human Cardiac Troponin I full length protein (ab50803)

Overview

Description

  • NatureRecombinant
  • SourceE. coli
  • Amino Acid Sequence
    • SpeciesHuman
    • Amino acids0 to 0

Specifications

Our Abpromise guarantee covers the use of ab50803 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Western blot

  • Purity> 90 % by SDS-PAGE.
    Combination of ammonium sulfate precipitation and ion exchange chromatography. Purity is greater than 90% by scanning SDS-PAGE.
  • FormLiquid
  • Additional Notes


    ab50803 contains no human or animal products.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 0.5M Sodium chloride, 60mM Beta mercaptoethanol, 20mM Tris HCl, pH 7.5

General info

  • Alternative names
    • cardiac muscle
    • Cardiac troponin I
    • Cardiomyopathy, familial hypertrophic, 7, included
    • CMD1FF
    • CMD2A
    • CMH7
    • cTnI
    • Familial hypertrophic cardiomyopathy 7
    • MGC116817
    • RCM1
    • Tn1
    • Tni
    • TNN I3
    • TNNC 1
    • TNNC1
    • TNNI3
    • TNNI3_HUMAN
    • Troponin I
    • Troponin I cardiac
    • Troponin I cardiac muscle
    • Troponin I cardiac muscle isoform
    • Troponin I type 3 cardiac
    • troponin I, cardiac 3
    • TroponinI
    • Ttroponin I type 3 (cardiac)
    see all
  • FunctionTroponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
  • Involvement in diseaseDefects in TNNI3 are the cause of cardiomyopathy familial hypertrophic type 7 (CMH7) [MIM:613690]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
    Defects in TNNI3 are the cause of cardiomyopathy familial restrictive type 1 (RCM1) [MIM:115210]. RCM1 is an heart muscle disorder characterized by impaired filling of the ventricles with reduced diastolic volume, in the presence of normal or near normal wall thickness and systolic function.
    Defects in TNNI3 are the cause of cardiomyopathy dilated type 2A (CMD2A) [MIM:611880]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
    Defects in TNNI3 are the cause of cardiomyopathy dilated type 1FF (CMD1FF) [MIM:613286]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
  • Sequence similaritiesBelongs to the troponin I family.
  • Information by UniProt

References for Human Cardiac Troponin I full length protein (ab50803)

ab50803 has not yet been referenced specifically in any publications.

Product Wall


The epitope for ab38210 Anti-cardiac Troponin I antibody [MF4] has been identified at aa190-196 [P19429 (TNNI3_HUMAN) Reviewed, UniProtKB/Swiss-Prot].



While we are still awaiting the PI information from the lab regarding ab5080...

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I have been in contact with the lab regarding ab50803. They have confirmed that ab50803 and ab51319 are recombinant single chain cardiac troponin I-C polypeptides that are superior calibration and control materials for cardiac troponin I immunoassays. ...

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Thank you for contacting us.
We have following anti Cardiac Troponin IgGs.
http://www.abcam.com/cardiac-troponin-i-antibody-ab47003.html
http://www.abcam.com/cardiac-troponin-i-antibody-284-19c7-ab19615.html
http://www.abcam.com/cardia...

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I am sorry this product did not contain the volumeas stated on the datasheet and for the inconven...

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I am very pleased to hear you would like to accept our offer and test ab50803 in ELISA. This code will give you: 1 freePROTEINbefore the expiration date. T...

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Thank you for calling Abcam yesterday.

I have talked to our lab regarding the conjugation of ab115704 to FITC. Below are the details that they have provided:

We could aim to supply 50ug of FITC labeled antibody in about 2 weeks, depen...

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Thank you for contacting us. I would recommend to use : 1) For the detection of Cardiac Troponin T : - ab45932 as capture antibody (directed against amino acids 64-82) www.abcam.com/ab45932 , - ab9937 as protein target, www.abcam.c...

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Thank you for your enquiry. I can confirm that ab50803 Cardiac Troponin I protein would be the most suitable for use with ab19615 Anti-Cardiac Troponin I antibody [284 (19C7)]. This is becuase it is full length recombinant human protein and shou...

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