Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human

Specifications

Our Abpromise guarantee covers the use of ab39725 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: 0.02% Sodium Azide
    Constituents: 0.1% BSA, PBS, pH 7.2

General Info

  • Alternative names
    • Apoptotic cysteine protease Mih1/TX
    • CASP-4
    • CASP4
    • CASP4_HUMAN
    • Caspase 4 apoptosis related cysteine peptidase
    • Caspase-4 subunit 2
    • Caspase4
    • ICE(rel)-II
    • ICE(rel)II
    • ICEREL II
    • ICH2
    • Mih1/TX
    • Protease ICH-2
    • Protease TX
    • TX
    see all
  • Function
    Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves caspase-1.
  • Tissue specificity
    Widely expressed, with highest levels in spleen and lung. Moderate expression in heart and liver, low expression in skeletal muscle, kidney and testis. Not found in the brain.
  • Sequence similarities
    Belongs to the peptidase C14A family.
    Contains 1 CARD domain.
  • Post-translational
    modifications
    The two subunits are derived from the precursor sequence by an autocatalytic mechanism or by cleavage by Caspase-8.
  • Information by UniProt

References

ab39725 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab39725.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up