Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman

Associated products

Specifications

Our Abpromise guarantee covers the use of ab71984 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

    Western blot

    Blocking - Blocking peptide for Anti-Caspase 4 antibody (ab25898)

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.

    Preservative: 0.02% Sodium Azide
    Constituents: 0.1% BSA, PBS, pH 7.2

General Info

  • Alternative names
    • Apoptotic cysteine protease Mih1/TX
    • CASP-4
    • CASP4
    • CASP4_HUMAN
    • Caspase 4 apoptosis related cysteine peptidase
    • Caspase-4 subunit 2
    • Caspase4
    • ICE(rel)-II
    • ICE(rel)II
    • ICEREL II
    • ICH2
    • Mih1/TX
    • Protease ICH-2
    • Protease TX
    • TX
    see all
  • FunctionInvolved in the activation cascade of caspases responsible for apoptosis execution. Cleaves caspase-1.
  • Tissue specificityWidely expressed, with highest levels in spleen and lung. Moderate expression in heart and liver, low expression in skeletal muscle, kidney and testis. Not found in the brain.
  • Sequence similaritiesBelongs to the peptidase C14A family.
    Contains 1 CARD domain.
  • Post-translational
    modifications
    The two subunits are derived from the precursor sequence by an autocatalytic mechanism or by cleavage by Caspase-8.
  • Information by UniProt

References for Human Caspase 4 peptide (ab71984)

ab71984 has not yet been referenced specifically in any publications.

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