Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      C-EYENRIRAYSTPDK
    • Amino acids
      113 to 126

Associated products

Specifications

Our Abpromise guarantee covers the use of ab126461 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-CBARA1 antibody (ab115025)

  • Form
    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

  • Reconstitution
    Resuspend in water or in neutral buffer

General Info

  • Alternative names
    • Allergen Hom s 4
    • ara CALC
    • atopy related autoantigen
    • atopy related autoantigen CALC
    • Atopy-related autoantigen CALC
    • CALC
    • calcium binding atopy related autoantigen 1
    • Calcium uptake protein 1
    • calcium uptake protein 1, mitochondrial
    • Calcium-binding atopy-related autoantigen 1
    • CBARA1
    • EFHA3
    • FLJ12684
    • MICU1
    • MICU1_HUMAN
    • mitochondrial
    • mitochondrial calcium uptake 1
    • MPXPS
    see all
  • Function
    Key regulator of mitochondrial calcium uptake required for calcium entry into mitochondrion. May act as a calcium sensor via its EF-hand domains, gating the activity of a calcium channel partner. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG.
  • Tissue specificity
    Expressed in epithelial cell line. Strongly expressed in epidermal keratinocytes and dermal endothelial cells.
  • Sequence similarities
    Belongs to the MICU1 family.
    Contains 2 EF-hand domains.
  • Domain
    The EF-hand domains are required for mitochondrial calcium homeostasis function.
  • Cellular localization
    Mitochondrion inner membrane.
  • Information by UniProt

References

ab126461 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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