The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-CBFb antibody (ab33516)
Purity of this peptide: >70%
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Core binding factor beta subunit
core binding factor subunit beta
Core-binding factor subunit beta
Polyomavirus enhancer binding protein 2 beta subunit
Polyomavirus enhancer-binding protein 2 beta subunit
SL3 3 enhancer factor 1 beta subunit
SL3 3 enhancer factor 1 subunit beta
SL3-3 enhancer factor 1 subunit beta
SL3/AKV core binding factor beta subunit
SL3/AKV core-binding factor beta subunit
CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters. CBFB enhances DNA binding by RUNX1.
Involvement in disease
Note=A chromosomal aberration involving CBFB is associated with acute myeloid leukemia of M4EO subtype. Pericentric inversion inv(16)(p13;q22). The inversion produces a fusion protein that consists of the 165 N-terminal residues of CBF-beta (PEPB2) with the tail region of MYH11.