Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceC-REFVSISSPAHVAT
    • Amino acids893 to 906

Associated products

Specifications

Our Abpromise guarantee covers the use of ab22874 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-CBL antibody (ab2235)

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • 4732447J05Rik
    • C CBL
    • Cas Br M (murine) ecotropic retroviral transforming sequence
    • Casitas B lineage lymphoma proto oncogene
    • Casitas B-lineage lymphoma proto-oncogene
    • cbl
    • CBL 2
    • CBL_HUMAN
    • CBL2
    • E3 ubiquitin protein ligase CBL
    • E3 ubiquitin-protein ligase CBL
    • Oncogene CBL2
    • Proto oncogene c CBL
    • Proto-oncogene c-CBL
    • RGD1561386
    • RING finger protein 55
    • RNF55
    • Signal transduction protein CBL
    see all
  • FunctionParticipates in signal transduction in hematopoietic cells. Adapter protein that functions as a negative regulator of many signaling pathways that start from receptors at the cell surface. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including PDGFA, EGF and CSF1, and terminates signaling.
  • PathwayProtein modification; protein ubiquitination.
  • Involvement in diseaseDefects in CBL are the cause of Noonan syndrome-like disorder (NSL) [MIM:613563]. NSL is a syndrome characterized by a phenotype reminiscent of Noonan syndrome. Clinical features are highly variable, including facial dysmorphism, short neck, developmental delay, hyperextensible joints and thorax abnormalities with widely spaced nipples. The facial features consist of triangular face with hypertelorism, large low-set ears, ptosis, and flat nasal bridge. Some patients manifest cardiac defects.
  • Sequence similaritiesContains 1 Cbl-PTB (Cbl-type phosphotyrosine-binding) domain.
    Contains 1 RING-type zinc finger.
    Contains 1 UBA domain.
  • DomainThe RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.
    The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.
  • Post-translational
    modifications
    Phosphorylated on tyrosine residues by EGFR, SYK, FYN and ZAP70 (By similarity). Phosphorylated on tyrosine residues by INSR.
  • Cellular localizationCytoplasm.
  • Information by UniProt

References for Human CBL peptide (ab22874)

ab22874 has not yet been referenced specifically in any publications.

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