Overview

  • Product name
    Human CCKAR peptide

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      RFLLPPNDVMQQSWH
    • Amino acids
      197 to 210

Associated products

Specifications

Our Abpromise guarantee covers the use of ab42262 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-CCKAR antibody (ab14441)

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. After reconstitution store at -20ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 0.1% Acetic acid

General Info

  • Alternative names
    • CCK A
    • CCK A receptor
    • CCK AR
    • CCK-A receptor
    • CCK1 R
    • CCK1-R
    • CCK1R
    • CCKA
    • CCKA receptor
    • CCKR Type A
    • CCKRA
    • Cholecystokinin 1 receptor
    • Cholecystokinin A receptor
    • Cholecystokinin receptor type A
    • Cholecystokinin type A receptor
    see all
  • Relevance
    The cholecystokinin (CCK) family of peptide hormones have been implicated in numerous important physiologic events. These appear to be mediated through 2 general classes of receptors, A (CCKAR)and B (CCKBR), based on their binding affinities for CCK/gastrin family peptides. Through binding to class A receptors, CCK is a major physiologic mediator of gallbladder contraction and pancreatic enzyme secretion. It appears to play a role in slowing gastric emptying, relaxation of the sphincter of Oddi, and potentiation of insulin secretion. Further, it has been implicated as a mediator of pancreatic growth and tumorigenesis. Class A receptors have also been described in the anterior pituitary, myenteric plexus, and regions of the central nervous system, where they have been implicated in the pathogenesis of feeding disorders, Parkinson disease, schizophrenia, and drug addiction.
  • Cellular localization
    Integral membrane protein

References

ab42262 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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