Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceVHRWPSARVRQTWS
    • Amino acids206 to 219

Associated products

Specifications

Our Abpromise guarantee covers the use of ab42263 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-CCKBR antibody (ab14440)

  • FormLyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. After reconstitution store at -20ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 0.1% Acetic acid

  • ReconstitutionResuspend in 0.1% acetic acid for required concentration.

General Info

  • Alternative names
    • CCK B
    • CCK B receptor
    • CCK BR
    • CCK-B receptor
    • CCK-BR
    • CCK2 R
    • CCK2 receptor
    • CCK2-R
    • CCKB
    • CCKB receptor
    • CCKBR
    • CCKR Type B
    • CCKRB
    • Cholecystokinin 2 receptor
    • Cholecystokinin B receptor
    • Cholecystokinin-2 receptor
    • Cholecystokinin2 receptor
    • CholecystokininB receptor
    • GASR
    • GASR_HUMAN
    • Gastrin receptor
    • Gastrin/cholecystokinin type B receptor
    • Gastrin\cholecystokinin brain receptor
    see all
  • FunctionReceptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
    Isoform 2 is constitutively activated and may regulate cancer cell proliferation via a gastrin-independent mechanism.
  • Tissue specificityIsoform 1 is expressed in brain, pancreas, stomach, the colon cancer cell line LoVo and the T-lymphoblastoma Jurkat, but not in heart, placenta, liver, lung, skeletal muscle, kidney or the stomach cancer cell line AGS. Expressed at high levels in the small cell lung cancer cell line NCI-H510, at lower levels in NCI-H345, NCI-H69 and GLC28 cell lines, not expressed in GLC19 cell line. Within the stomach, expressed at high levels in the mucosa of the gastric fundus and at low levels in the antrum and duodenum. Isoform 2 is present in pancreatic cancer cells and colorectal cancer cells, but not in normal pancreas or colonic mucosa. Isoform 3 is expressed in brain, pancreas, stomach, the stomach cancer cell line AGS and the colon cancer cell line LoVo.
  • Sequence similaritiesBelongs to the G-protein coupled receptor 1 family.
  • Cellular localizationCell membrane.
  • Information by UniProt

References for Human CCKBR peptide (ab42263)

ab42263 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"